Retinal and choroidal vasculature changes in healthy and high-risk pregnancies

项目摘要/摘要： 这个应用程序请求为一个使用视网膜图片改善孕产妇胎儿保健的项目提供资金，该项目名为 光学相干断层血管造影术。怀孕是一个复杂的过程，可能导致并发症。 比如早产和先兆子痫。每10个怀孕中就有1个早产，而且还在增加 由于体外受精率的提高、产妇年龄的提高和多胎妊娠。先兆子痫, 发生在所有妊娠中的约5%-8%，是整个孕产妇发病率和死亡率的重要原因 整个世界。这项研究将对孕妇进行全程光学相干断层扫描血管成像。 怀孕，然后跟随他们，直到怀孕完成后。这项研究假设会有 是视网膜成像的早期发现，能够预测早产等晚期妊娠并发症 分娩和先兆子痫。我们将通过利用一家大型、高流量的诊所来最大限度地招聘和留住员工 学术中心，并在现场放置摄像头。通过这项研究的完成，我们希望开发出一种 这是一种更好地监测高危妊娠和研究早期干预措施的方法。

Project Summary/Abstract: This application requests funding for a project to improve maternal fetal healthcare using retinal pictures called optical coherence tomography angiography. Pregnancy is a complex process that can lead to complications such as preterm birth and preeclampsia. Preterm birth occurs in about 1 out of 10 pregnancies and is increasing due to increasing rates of in vitro fertilization, advanced maternal age, and multiple gestations. Preeclampsia, occurring in about 5-8% of all pregnancies, is an important cause of maternal morbidity and mortality throughout the world. This study will image pregnant women with optical coherence tomography angiography throughout pregnancy and then follow them until after the completion of pregnancy. The study hypothesizes that there will be early findings on retinal imaging that will be able to predict late-term pregnancy complications such as preterm birth and preeclampsia. We will maximize recruitment and retention by utilizing a large high-volume clinic in an academic center and placing a camera on site. Through the completion of this research, we hope to develop a way to better monitor high risk pregnancies and enable the study of early interventions.