ShEEP Request for a high speed fluorescent slide scanning system

该提案描述了购买PerkinElmer Vectra北极星高速滑梯的资金申请 扫描系统。拟议的设备是一种最先进的系统，旨在提供高质量的- 显微镜具有更高的灵敏度和更快的吞吐量，以及自动化功能，具有大型和 安全的数据存储，这将允许退伍军人管理局调查人员在几分钟内对其样本进行成像，而不是 几个小时。这种成像系统将允许退伍军人管理局资助的波士顿医疗系统的调查人员 (VABHS)通过高性能自动化执行高通量和超分辨率显微镜 采集和分析，包括标记的大规模量化、全脑重建和 投影映射。该系统的采购得到了退伍军人事务部资助的6名以上调查人员的支持 VABHS。拟议的系统将在多个研究领域进一步研究，如胃肠道疾病， 神经科学和血液系统恶性肿瘤。本申请描述了我们对建议的 设备，其技术规格，关于如何改进退伍军人管理局资助的研究的信息，以及 它的管理。

This proposal describes a request for funds to purchase the PerkinElmer Vectra Polaris high speed slide scanning system. The proposed equipment is a state-of-the-art system designed to provide high-quality- microscopy with increased sensitivity and faster throughput as well as automated functionality with large and secure data storage, which would allow VA investigators to image their samples within minutes instead of hours. This imaging system would allow the VA-funded investigators at the VA Boston Healthcare System (VABHS) to perform high throughput and super-resolution microscopy with high performance automated acquisition and analysis, including large scale quantification of markers, whole brain reconstruction and projection mapping. Acquisition of the system is supported by more than 6 VA-funded investigators at the VABHS. The proposed system will further research in multiple areas of study, such as gastrointestinal disease, neuroscience, and hematological malignancies. The present application describes our need for the proposed equipment, its technical specifications, information on how it can improve VA-funded research, and a plan for its administration.