ShEEP Request for ACQUITY UPLC H-Class PLUS Bio System

项目摘要 测定儿茶酚胺(去甲肾上腺素和肾上腺素)、神经递质的能力 (多巴胺和5-羟色胺)，核苷酸[一磷酸腺苷(AMP)，二磷酸腺苷 (ADP和三磷酸腺苷(ATP))、糖核苷酸(UDP葡萄糖)、糖磷酸 [葡萄糖-1-磷酸(G1P)和葡萄糖-6-磷酸(G6P)、多糖及其衍生物] 组织或血浆样本将显著和积极地影响大量VA赞助的 与退伍军人相关的基础、转化和临床前生物医学/行为研究项目 目前在退伍军人事务部圣地亚哥医疗系统(VASDHS)进行的医疗保健。儿茶酚胺， 神经递质、核苷酸、糖磷酸盐、多聚糖和多聚糖衍生物受到几种 疾病状态包括高血压、糖尿病、肥胖、癌症、骨关节炎、成瘾和 创伤性精神障碍。我们是一个由11名目前获得VA荣誉奖资助的调查人员组成的小组，他们 将直接受益于收购ACQUITY UPLC H-Class plus Bio系统和光电二极管 阵列(PDA)和荧光检测器。我们的项目涵盖了广泛的领域和 研究包括肾病/高血压、内分泌学、神经学、麻醉学、心脏病学、 泌尿外科和外科。收购ACQUITY UPLC H级PLUS Bio系统 光电二极管阵列(PDA)和荧光检测器不仅将影响基础临床前研究 在VASDHS，也有望通过改善患者的病情发挥强大和积极的作用 临床护理和支持退伍军人管理局的医疗保健使命。

Project Summary The capability to measure catecholamines (norepinephrine and epinephrine), neurotransmitters (dopamine and serotonin), nucleotides [adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP)], sugar nucleotides (UDP glucose), sugar phosphates [glucose 1 phosphate (G1P) and glucose 6 phosphate (G6P), glycans and glycan derivatives] in small tissue or plasma samples will significantly and positively impact a large number of VA-sponsored projects in basic, translational and preclinical biomedical/behavioral research relevant to Veteran’s healthcare currently conducted at the VA San Diego Healthcare System (VASDHS). Catecholamines, neurotransmitters, nucleotides, sugar phosphates, glycans and glycan derivatives are affected several disease states including hypertension, diabetes, obesity, cancer, osteoarthritis, addiction and traumatic disorders. We are a group of 11 currently funded investigators with VA Merit Awards who will directly benefit from acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors. Our projects encompass a wide range of fields and research, including nephrology/hypertension, endocrinology, neurology, anesthesiology, cardiology, urology, and surgery. The acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors will not only impact basic pre-clinical research at VASDHS, but also is expected to have a strong and positive effect through improvement of patient clinical care and supporting the VA healthcare mission.