Core C - Stem Cell Core

骨干细胞核心（Core C）的主要功能是分离和分配骨髓- 来源的间充质干/祖细胞（BMSC）的研究人员的个人 项目，并为使用细胞提供技术支持。一个关键的组成部分， 拟议的计划项目的成功是BMSC的可用性，因为所有项目 需要这些细胞。因此，集中的核心设施生产优质电池至关重要 这一动态协调的计划项目的成功。这一核心将有利于 通过降低成本，为研究提供质量控制， 程序，并加强多学科之间的合作，以实现更大的 通过综合方法获得科学收益。此外，细胞的生产和分布 将确保所有研究从相同谱系的细胞开始， 背景具体目标是：1。分离、表征和分配小鼠BMSC， 人骨髓MSC（hMSC），和2.提供持续的技术支持， 常规MSC培养和分化（成骨、成脂和成软骨） 测定。通过实现这些目标，该核心将作为一种独特的资源， 小鼠和人类骨髓间充质干细胞和技术援助的个别项目，以及 其他对衰老相关研究感兴趣的格鲁吉亚摄政大学研究人员， 代谢性骨病或干细胞研究。

The main function of the Bone Stem Cell Core (Core C) is to isolate and distribute bone marrow- derived mesenchymal stem/progenitor cells (BMSCs) to the investigators of the individual projects, and to provide technical support for use of the cells. A key component essential to the success of the proposed Program Project is the availability of BMSCs because all projects require these cells. Thus, a centralized Core facility for the production of quality cells is crucial to the success of this dynamically coordinated Program Project. This Core will benefit the research efforts of individual investigator by reducing costs, providing quality control for study procedures, and enhancing collaborations among multiple disciplines to achieve greater scientific gain through an integrated approach. In addition, production and distribution of cells from a centralized facility will ensure that all studies start with cells of the same lineages and background. The Specific Aims are: 1. Isolate, characterize and distribute mouse BMSCs, human bone marrow MSCs (hMSCs), and 2. Provide ongoing technical support for hypoxic and conventional MSC culture and differentiation (osteogenic, adipogenic, and chondrogenic) assays. By achieving these objectives, this Core will function as a unique resource to provide mouse and human BMSCs and technical assistance to the individual projects, as well as to other Georgia Regents University investigators who are interested in studies related to aging, metabolic bone diseases, or stem cell research.