University of Pittsburgh MACS/WIHS CCS

项目摘要/摘要 匹兹堡大学(PITT)临床研究网站(CRS)与我们的 俄亥俄州立大学(OSU)多中心艾滋病队列研究的协作临床站点 (MACS)/妇女机构间艾滋病毒研究(WIHS)联合队列研究(MACS/WIHS CCS)是为了支持， 通过利用优势和科学，补充和加速CCS统一科学议程(美国) CRS调查人员的专业知识。我们建议继续扩大我们35年来对 艾滋病毒感染的自然病史。这项拨款申请的中心假设是，作为拥有 慢性HIV感染年龄，他们患严重的、缩短生命的合并症的风险比 年龄相当，未感染的人，这可能在男性和女性之间有所不同。根据NIH RFA的指导- HL-19-008，CRS将提供强有力和包容性的领导，专注于美国的五个具体目标，以及 为其他五个目标提供有针对性的协作支持，以提高我们对流行病学、临床、 男性和女性慢性共病与HIV感染的病毒学、免疫学和行为学关系 这代表了美国目前的艾滋病毒流行。CRS还将提供纵向数据和 由CCS和非CCS研究人员领导的艾滋病毒合作研究项目的生物标本。这 研究对于完成我们改善临床管理、提高存活率和控制力的使命是重要的。 预防和治疗艾滋病毒感染。CRS将提供最新和最具创新性的流行病学资料， 临床和实验室方法和心理社会研究方案，以实现我们的5个领导力特定 目标。PIT/OSU CRS将由MPI和几个具有广泛专业知识的COI领导 领导五个高度专业化的CCS美国特定目标(目标2：肺/睡眠[莫里斯]；目标3：神经认知 [Becker]；目标6：艾滋病毒/病因学[Macatangay]；目标7：心理社会[停滞]；目标9：平台[Rinaldo， 金斯利])，并为其他5个具体目标(目标1：心血管[金斯利，马丁森]，目标)提供见解 4：老龄化[Koletar]，目标5：癌症[Jenkins]，目标8：健康差距[Krier]，目标10：职业发展[Sluis- 作者声明：[Cremer]。通过这项计划，PIT/OSU CRS解决了FOA的基本理由，即 需要更充分地了解艾滋病毒、其治疗方法和免疫抑制的遗留问题，以优化健康 艾滋病毒携带者的名单。

PROJECT SUMMARY/ABSTRACT The overarching strategy of the University of Pittsburgh (Pitt) clinical research site (CRS) together with our collaborative clinical site at The Ohio State University (OSU) of the Multicenter AIDS Cohort Study (MACS)/Woman’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS CCS) is to support, complement and accelerate the CCS unified scientific agenda (USA) by leveraging the strengths and scientific expertise of CRS investigators. We propose to continue to expand on our 35 years of extensive research on the natural history of HIV infection. The central hypothesis of this grant application is that, as men and women with chronic HIV infection age, they increase their risks for serious, life-shortening comorbidities beyond those of comparable age, uninfected persons, and this could differ between men and women. As directed by NIH RFA- HL-19-008, the CRS will provide robust and inclusive leadership focused on five specific aims of the USA, and targeted collaborative support for the five other aims, to improve our understanding of the epidemiologic, clinical, virologic, immunologic, and behavioral relationships of HIV infection to chronic comorbidities in men and women that represent the current HIV epidemic in the United States. The CRS will also contribute longitudinal data and biological specimens for collaborative research projects on HIV led by CCS and non-CCS investigators. This research is important to fulfill our mission of improving clinical management, increasing survival and controlling, preventing and curing HIV infection. The CRS will provide the most current and innovative epidemiological, clinical and laboratory methods and psychosocial research protocols to accomplish our 5 leadership specific aims. The Pitt/OSU CRS will be led by a triumvirate of MPIs and several CoIs with broad expertise needed to lead five highly specialized CCS USA Specific Aims (Aim 2: Pulmonary/Sleep [Morris]; Aim 3: Neurocognitive [Becker]; Aim 6: HIV/Pathogenesis [Macatangay]; Aim 7: Psychosocial [Stall]; Aim 9: Platform [Rinaldo, Kingsley]) and to provide insight for the 5 other Specific Aims (Aim 1: Cardiovascular [Kingsley, Martinson], Aim 4: Aging [Koletar], Aim 5: Cancer [Jenkins], Aim 8: Health Disparities [Krier], Aim 10: Career Development [Sluis- Cremer]. With this plan the Pitt/OSU CRS addresses the basic justification of the FOA, i.e., that the impact of HIV, its treatment, and the legacy of immune suppression need to be more fully understood to optimize the health of people living with HIV.