Therapeutic in Situ Analgesic Implant for improved Oral-Facial Post-Operative Pain Outcomes

项目总结 术后人群的止痛仍然是一项重要的健康需求，呼吁 改善安全性和结果衡量标准的创新疗法。FDA新药 安全警告和关注术后止痛的研究强调了 迫切需要可用于常见临床方案的新方法。 因此，新的治疗选择是安全的，并在缓解疼痛方面提供额外的好处 都是需要的。在这项提案中，一种创新的外科密封剂技术的开发是 建议在手术伤口床层面发挥作用，并积极提供局部 用于治疗术后疼痛的药物。新剂型 将对几种止痛方案进行评估，以了解它们封闭伤口和提供 适当的疼痛管理。

PROJECT SUMMARY Analgesia for post-operative populations remains a significant health need that calls for innovative therapies which improve both safety and outcome measures. Recent FDA drug safety warnings and studies focusing on post-operative analgesia have highlighted the imperative need for new approaches that can be utilized for common clinical scenarios. Accordingly, novel treatment options that are safe and afford additional benefit in relief of pain are needed. In this proposal, the development of an innovative surgical sealant technology is proposed that functions at the level of the surgical wound bed and actively delivers local pharmacologic agents to therapeutically address post-operative pain. New formulations of several analgesic regimens will be assessed for their ability to seal wounds and provide appropriate pain management.