ShEEP Request for Multi-Modal Brain Imaging System

我们的退伍军人医疗保健系统(VANCHCS)为超过500,000名退伍军人提供服务，是 全国最大的集水区，包括一个很大的农村地区。我们的神经科学研究中心 VANCHCS马丁内斯校区在以下领域拥有30年的开创性脑损伤研究历史 中风和创伤性脑损伤的基础脑研究。在过去的几年里，我们的研究重点 已经发展到包括翻译和干预研究，例如关于正念功效的研究， 有脑损伤和创伤后病史个体的目标训练和应激接种训练 应激障碍(PTSD)。为了进一步加强我们对退伍军人的研究，我们正在申请资金，用于 结合干式脑电和功能近红外的便携式多模式脑成像系统 光谱学(FNIR)。这个系统将允许我们收集同步的电生理和 使用舒适、简单易用的便携式设备获取老年和脑损伤患者的血流动力学反应数据 耳机。该系统还包括传感器，以集成生理生物标记，如心率、电偶 皮肤反应(GSR)和呼吸频率。由于它的设计，可以在研究的同时进行录音 患者从事行为任务，如行走或操作驾驶模拟器。重要的是 这种便携式成像系统将使我们能够收集功能脑成像和生物标志物数据 通常被排除在大脑研究活动之外的患者，比如远在农村的退伍军人， 卧床/呆在家里的患者(例如，急性/急性中风后的患者)，以及接受MRI检查的患者 禁忌症(如幽闭恐惧症、起搏器等)。这一额外的脑功能成像工具 将有力地加强我们目前的神经科学研究计划，并提高我们申请 竞争性赠款资金。目前，我们的神经科学研究小组有几个由退伍军人管理局和美国国立卫生研究院资助的 将受益于这种大脑成像工具的研究：1)中风对驾驶性能的影响；2) 正念训练的随机对照试验；3)中风后行走能力的恢复；4)执行 在脑损伤/创伤后应激障碍中的功能；5)纵向中风的康复；以及6)计算机化的神经心理测试 症状前阿尔茨海默病。最终，我们的目标是致力于改善临床 为我们的脑损伤和相关疾病的退伍军人患者提供诊断和治疗干预。

Our VA Northern California Health Care System (VANCHCS) serves over 500,000 Veterans and is one of the largest catchments in the country, including a large rural component. Our Neuroscience Research Center on the VANCHCS Martinez campus has a 30-year history of groundbreaking Brain Injury Research in the area of basic brain research on stroke and traumatic brain injury (TBI). In the last several years, our research focus has grown to include translational and intervention research, such as studies on the efficacy of mindfulness, goal-training, and stress-inoculation training in individuals with a history of brain injury and post-traumatic stress disorder (PTSD). To further enhance our research with Veteran patients, we are requesting funds for a portable Multi-Modal Brain Imaging System that combines dry EEG and functional near-infrared spectroscopy (fNIRS). This system would allow us to collect synchronized electrophysiological and hemodynamic response data from aging and brain-injured patients with a comfortable, simple-to-use portable headset. The system also includes sensors to integrate physiological biomarkers such as heart rate, galvanic skin response (GSR), and respiration rate. Due to its design, recordings can be made while research patients are engaged in behavioral tasks, such as ambulation or operating a driving simulator. Importantly, this portable Imaging System would enable us to collect functional brain imaging and biomarker data from patients who are typically left out of brain research activities, such as Veterans in distant rural settings, bed-bound/home-bound patients (e.g., acute/post-acute stroke patients), and patients with MRI contraindications (e.g., claustrophobia, pacemakers, etc.). This additional functional brain imaging tool would strongly enhance our current neuroscience research program and increase our ability to apply for competitive grant funding. Currently, our Neuroscience Research group has several VA- and NIH-funded studies that would benefit from this brain imaging tool: 1) impact of stroke on driving performance; 2) randomized controlled trials of mindfulness training; 3) recovery of ambulation post-stroke; 4) executive functioning in TBI/PTSD; 5) longitudinal stroke recovery; and 6) computerized neuropsychological testing in presymptomatic Alzheimer’s Disease. Ultimately, our goal is to work towards improved clinical diagnostics and treatment interventions for our Veteran patients with brain injuries and related disorders.