Executive Functioning in OEF/OIF Veterans with Traumatic Brain Injury

患有脑外伤的 OEF/OIF 退伍军人的执行功能

基本信息

项目摘要

DESCRIPTION (provided by applicant): Project Summary/Abstract Traumatic brain injury is a significant health problem in a large number of military personnel returning from Iraq and Afghanistan. Unfortunately, many individuals with mild traumatic brain injuries stemming from exposure to blasts or other accidents do not get properly evaluated and treated, due to the subtle nature of their injuries. Moreover, the brain changes associated with mild traumatic brain injury often go undetected with standard brain imaging. Other issues, such as coexisting emotional disorders, the stigma of a possible mental disability, their young age, and the lack of awareness of such cognitive changes, can each affect outcome and further complicate recovery. The current study proposes to conduct a comprehensive battery of tests in returning veterans with mild traumatic brain injury in order to document impairments in cognitive skills, such as reasoning and problem solving. Such abilities are critical as our veteran patients attempt to return to work and school. In addition, we will use a recently developed form of MRI brain imaging, known as diffusion tensor imaging, which can identify subtle brain changes that are not detected with standard MRI scans. In this way, we will be able to identify cognitive deficits and their relationship to brain injury in this patient group. This study will help us to disentangle difficulties stemming from other co-existing symptoms, such as emotional disorders, versus those problems stemming directly from trauma to the brain. Improved diagnostics and treatment for our veteran patients with traumatic brain injury is critically needed. Data from this study will provide important information regarding the characteristic cognitive profile of patients with mild traumatic brain injury and provide direction for proper diagnostic and treatment procedures within the VA system. Moreover, findings from this study will clarify the brain basis of cognitive deficits in this patient group. PUBLIC HEALTH RELEVANCE: Project Narrative The current study is aimed at identifying and characterizing the range of deficits experienced by veterans returning from Iraq and Afghanistan who have sustained mild traumatic brain injuries following exposure to blasts and other accidents. Due to the subtlety of deficits associated with mild traumatic brain injury, patients are often not adequately evaluated or diagnosed. When they attempt to return to work or school, many of our veterans experience difficulty due to lapses in memory, concentration, and other thinking skills. Since many of the standardized tasks traditionally used with this patient group are not sensitive to the subtle nature of their deficits, we will test patients on newer tests that are more similar to everyday tasks. In addition, we will use a new form of MRI brain imaging, called diffusion tensor imaging, that will allow us to detect subtle brain changes in this patient group that cannot be detected with standard clinical scans. In this way, we can help identify the neurologic basis of deficits in veterans with mild traumatic brain injury and disentangle these neurologic causes from other psychological causes, such as emotional changes. Data from this study will be directly translatable into the clinical realm, as it will provide critical information regarding the characteristic cognitive profile of patients with mild traumatic injury and provide direction for proper diagnostic and treatment procedures within the VA system. Experimental findings from this study can be directly used to aid in devising new strategies for rehabilitation in patients with mild traumatic injury. The findings will provide a basis for strategies to ultimately improve our patients' problem solving and multi-tasking abilities, which will in turn facilitate their ability to return to work and school. Brain imaging findings from this study will provide the basis for improved diagnostics for mild traumatic brain injury at the VA, as well as clarify the brain basis of cognitive deficits in this patient group.
描述(由申请人提供): 创伤性脑损伤是一个重大的健康问题,在大量的军事人员从伊拉克和阿富汗返回。不幸的是,许多因暴露于爆炸或其他事故而造成轻度创伤性脑损伤的人由于其损伤的微妙性质而没有得到适当的评估和治疗。此外,与轻度创伤性脑损伤相关的脑变化通常无法通过标准脑成像检测到。其他问题,如共存的情绪障碍,可能的精神残疾的耻辱,他们的年轻,以及缺乏对这种认知变化的认识,都可能影响结果并使康复进一步复杂化。目前的研究建议对轻度创伤性脑损伤的退伍军人进行一系列全面的测试,以记录认知技能的障碍,如推理和解决问题。这些能力对于我们的退伍军人患者试图重返工作和学校至关重要。此外,我们将使用最近开发的MRI脑成像形式,称为扩散张量成像,它可以识别标准MRI扫描无法检测到的细微大脑变化。通过这种方式,我们将能够确定认知缺陷及其与该患者组脑损伤的关系。这项研究将帮助我们理清其他共存症状(如情绪障碍)引起的困难,以及直接来自大脑创伤的问题。我们迫切需要改善对创伤性脑损伤退伍军人患者的诊断和治疗。本研究的数据将提供关于轻度创伤性脑损伤患者特征性认知特征的重要信息,并为VA系统内的正确诊断和治疗程序提供指导。此外,这项研究的结果将阐明这一患者群体认知缺陷的大脑基础。 公共卫生关系: 项目叙述目前的研究旨在确定和表征从伊拉克和阿富汗返回的退伍军人所经历的赤字范围,这些退伍军人在暴露于爆炸和其他事故后遭受了轻度创伤性脑损伤。由于与轻度创伤性脑损伤相关的缺陷的微妙性,患者往往没有得到充分的评估或诊断。当他们试图返回工作或学校时,我们的许多退伍军人由于记忆力,注意力和其他思维能力的丧失而遇到困难。由于许多传统上用于该患者组的标准化任务对他们的缺陷的微妙性质不敏感,我们将对患者进行更类似于日常任务的新测试。此外,我们将使用一种新形式的MRI脑成像,称为扩散张量成像,这将使我们能够检测到这一患者群体的微妙大脑变化,这些变化是标准临床扫描无法检测到的。通过这种方式,我们可以帮助识别轻度创伤性脑损伤退伍军人的神经基础缺陷,并将这些神经原因与其他心理原因(如情绪变化)分开。本研究的数据将直接转化为临床领域,因为它将提供关于轻度创伤性损伤患者特征性认知特征的关键信息,并为VA系统内的正确诊断和治疗程序提供指导。这项研究的实验结果可以直接用于帮助设计新的策略,为轻度创伤性损伤患者的康复。这些发现将为最终提高患者解决问题和多任务处理能力的策略提供基础,这反过来将促进他们重返工作和学校的能力。本研究的脑成像结果将为改善VA轻度创伤性脑损伤的诊断提供基础,并阐明该患者组认知缺陷的脑基础。

项目成果

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Juliana V. Baldo其他文献

Juliana V. Baldo的其他文献

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{{ truncateString('Juliana V. Baldo', 18)}}的其他基金

Mindfulness-Based Stress Reduction to Improve Neuropsychological Functioning in Acquired Brain Injury
基于正念的减压可改善后天性脑损伤的神经心理功能
  • 批准号:
    10524747
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Impact of Left Hemisphere Stroke on Cognitive Functioning and Implications for Driving
左半球中风对认知功能的影响及其对驾驶的影响
  • 批准号:
    10295146
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Impact of Left Hemisphere Stroke on Cognitive Functioning and Implications for Driving
左半球中风对认知功能的影响及其对驾驶的影响
  • 批准号:
    10578655
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Impact of Left Hemisphere Stroke on Cognitive Functioning and Implications for Driving
左半球中风对认知功能的影响及其对驾驶的影响
  • 批准号:
    10041706
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Impact of Left Hemisphere Stroke on Cognitive Functioning and Implications for Driving
左半球中风对认知功能的影响及其对驾驶的影响
  • 批准号:
    9779452
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Multi-Modal Brain Imaging System
ShEEP 请求多模式脑成像系统
  • 批准号:
    9907326
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Mindfulness-Based Stress Reduction to Improve Neuropsychological Functioning in Acquired Brain Injury
基于正念的减压可改善后天性脑损伤的神经心理功能
  • 批准号:
    10290881
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Brain Biomarkers of Response to Treatment for Apraxia of Speech
言语失用症治疗反应的大脑生物标志物
  • 批准号:
    8826604
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Brain Biomarkers of Response to Treatment for Apraxia of Speech
言语失用症治疗反应的大脑生物标志物
  • 批准号:
    8678364
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Executive Functioning in OEF/OIF Veterans with Traumatic Brain Injury
患有脑外伤的 OEF/OIF 退伍军人的执行功能
  • 批准号:
    7750045
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

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