ShEEP Request for Ultrasound Imaging System

本申请是针对S-夏普公司ProspectT1High的超声成像系统 40 MHz探头和Indus多普勒血流速度的小鼠频率超声成像系统 系统。这台仪器将取代和升级我们目前的鼠标超声心动图系统，西门子 Acuson S2000超声波系统，探头为14 MHz。这件旧乐器是在2008年购买的，现在 现在11岁了。图像质量正在恶化，我们无法获得我们需要的细节和分辨率 要求。 申请的超声系统将支持退伍军人管理局资助的4个项目中的5个主要用户PI。每个专业 USER正在研究治疗心力衰竭的新方法，心力衰竭是世界上最常见、最致命的临床问题之一 退伍军人。PI使用回声系统通过量化大小来评估潜在治疗的疗效 左、右心室的功能以及心脏和主要动脉的血流。 旧金山VAMC的5位PI如下： 保罗·C·辛普森，医学博士，加州大学旧金山分校心脏病专家和医学教授。他的项目是“新奇的” 心力衰竭治疗中的肾上腺素能机制“(VA)，以及”一种治疗心力衰竭的肾上腺素能药物“ (美国国立卫生研究院)。 安东尼·贝克，博士，研究生物学家，加州大学旧金山分校医学教授。他的项目 《健康和慢性病中的右心功能》(VA)和《右室新疗法》 失败“(加州大学旧金山分校)。 Mary Nakamura，医学博士，加州大学旧金山分校内科医生兼医学教授，以及共同研究的皮乔尔·S·卡林纳医学博士， 加州大学旧金山分校心脏病专家和医学教授。他们的项目是“心脏的免疫机制” 改建“(Va)。 罗伯特·拉法伊博士，加州大学旧金山分校研究生物学家兼外科副教授。他的 项目是“糖尿病动脉粥样硬化发病机制及其治疗机会中的外体”(VA)， 和“高血糖和微RNA对动脉粥样硬化炎症的调节失调”(NIH)。 所要求的超声波系统将使以下项目的工作得以实现并大大加强 以上，并希望促进努力发现新的治疗心力衰竭的方法。

This request is for an Ultrasound Imaging System, the S-Sharp Corporation Prospect T1 High Frequency Ultrasound Imaging System For Mice, with a 40 MHz probe, and an Indus Doppler Flow Velocity System. This instrument will replace and upgrade our current mouse echocardiography system, a Siemans Acuson S2000 Ultrasound System, with a 14 MHz probe. This old instrument was purchased in 2008 and is now 11 years old. Image quality is deteriorating, and we are not able to get the detail and resolution we require. The requested ultrasound system will support 5 Major User PIs in 4 VA-funded projects. Each Major User is working toward new treatments for heart failure, one of the most common, deadly clinical problems in Veterans. The PIs use the echo system to assess the efficacy of potential treatments by quantifying the size and function of the left and right ventricles and flow in the heart and main arteries. The 5 PIs, all at the San Francisco VAMC, are as follows: Paul C. Simpson, MD, Staff Cardiologist and Professor of Medicine, UCSF. His projects are “Novel adrenergic mechanisms in heart failure therapy” (VA), and “An alpha-1A-adrenergic drug for heart failure” (NIH). Anthony J. Baker, PhD, Research Biologist SFVAHCS and Professor of Medicine, UCSF. His projects are “Right Heart Function in Health and Chronic Disease” (VA), and “Novel Therapy for Right Ventricular Failure” (UCSF). Mary Nakamura, MD, Staff Physician and Professor of Medicine, UCSF, and co-PI Joel S. Karliner MD, Staff Cardiologist and Professor of Medicine, UCSF. Their project is “Immune Mechanisms of Cardiac Remodeling” (VA). Robert Raffai, PhD, Research Biologist SFVAHCS and Associate Professor of Surgery, UCSF. His projects are “Exosomes in the Pathogenesis of Diabetic Atherosclerosis & its Treatment Opportunities” (VA), and “Hyperglycemia and MicroRNA Dysregulation of Inflammation in Atherosclerosis” (NIH). The requested ultrasound system will enable and greatly enhance the work in the projects named above, and hopefully facilitate the efforts to discover new treatments for heart failure.