2020 Biology of Spirochetes GRC/GRS

摘要 螺旋体是一个深分枝的细菌门，最初由它们的蛇形形状和 周质鞭毛。致病性螺旋体是许多全球重要的新兴和 再次出现的传染病，包括莱姆病、梅毒、钩端螺旋体病、复发发热和肠道 螺旋体病。此外，它们还参与多菌感染和宿主细菌内共生，以及 它们是病媒传播、环境和人畜共患感染的模型。高氏螺旋藻的生物学研究 研究会议(BoS GRC)和随之而来的Gordon研究研讨会(BoS GRS)，这是 由培训中的研究人员组织并以此为目标的培训，自1994年以来每两年举行一次，作为 将在结构和分类学上致力于此的研究人员聚集在一起的唯一科学会议 独特的细菌门。2020年BoS GRC和GRS计划旨在突出 螺旋体生物学和疾病发病机制研究的多样性。我们的首要目标是促进展示 并对螺旋体病发病机制和螺旋体的多样性和前沿研究进行了讨论 生物学，包括寄主相互作用和防御，免疫逃避和持续机制，生态学和 进化论、结构生物学和生理学。我们的第二个目标是促进所有人的职业发展 研究螺旋体的科学家。为了实现这些目标，我们邀请了36位演讲者参加2020年的BOS GRC， 其中许多人是第一次参加，其中包括三名实习生。我们已经预订了八个演讲时段。 “海报演讲”将从与会者提交的海报演示摘要中挑选出来。英国牛市 GRS将包括口头演示、海报演示和以职业选择为重点的小组讨论 科学。BoS GRC将包括一个“能量小时”，这是一个为所有会议参与者提供的非正式聚会 应对妇女在科学领域面临的挑战，并支持妇女在科学领域的专业成长。 GRC和GRS计划都反映了研究和该领域科学家的多样性， 作为发言者和讨论领导者的妇女和国际科学家的代表性很强。浩瀚无边 在过去的20年中，螺旋体研究的大部分主要进展都是从这些讨论中演变出来的 由BoS GRC促进的合作：2020年的会议努力继续这一值得称赞的做法 弹道。

Abstract The Spirochetes are a deeply-branching phylum of bacteria initially delineated by their serpentine shape and periplasmic flagella. Pathogenic spirochetes are the etiologic agents of many globally significant emerging and re-emerging infectious diseases, including Lyme disease, syphilis, leptospirosis, relapsing fever, and intestinal spirochetosis. In addition, they participate in polymicrobial infections and host-bacterial endosymbioses, and they are models for vector-borne, environmental, and zoonotic infections. The Biology of Spirochetes Gordon Research Conference (BoS GRC) and the accompanying Gordon Research Seminar (BoS GRS), which is organized by and targeted to researchers in training, have been held every two years since 1994 and serve as the only scientific meetings that bring together researchers who work on this structurally and taxonomically unique phylum of bacteria. The 2020 BoS GRC and GRS programs have been designed to highlight the diversity of research in spirochete biology and disease pathogenesis. Our first Aim is to promote presentation and discussion of diverse and cutting-edge research on spirochete disease pathogenesis and spirochete biology, including host interactions and defenses, immune evasion and persistence mechanisms, ecology and evolution, and structural biology and physiology. Our second Aim is to promote career development for all scientists studying spirochetes. To achieve these Aims, we have invited 36 speakers to the 2020 BoS GRC, many of whom are first-time attendees including three trainees. We have reserved eight speaking slots for “poster talks” that will be selected from the abstracts submitted by attendees for poster presentations. The BoS GRS will include oral presentations, poster presentations, and panel discussions focused on career options in science. The BoS GRC will include a “Power Hour”, an informal gathering for all meeting participants to address the challenges women face in science and to support the professional growth of women in science. Both the GRC and the GRS programs reflect the diversity of the research and the scientists in the field, with strong representation of women and international scientists as both speakers and discussion leaders. The vast majority of the major advances in spirochete research during the past 20 years evolved from the discussions and collaborations fostered by the BoS GRC: the 2020 conferences endeavor to continue this laudable trajectory.