2020 Oxygen Radicals Gordon Research Conference (GRC) and Gordon Research Seminar (GRS)

项目摘要 这项会议拨款提案寻求资金的戈登研究会议（GRC）的氧自由基： 化学反应，代谢和治疗发展的机会将在加利福尼亚州文图拉举行 2020年2月2日至7日，与戈登研究研讨会（GRS）的学员，由两个组织 学员（谢丽尔货车德韦特林和瑞亚Bovee），将于2020年2月1日至2日举行的GRC之前举行 在同一地点我们提出了一个令人兴奋的计划，汇集了氧化剂研究的不同领域， 将新氧化剂种类的最新发现与方法学进展、生物学研究 细胞器功能障碍和代谢，衰老，以及全体会议和圆桌会议讨论，重点是氧化还原- 临床开发中的药物。该计划包括高级科学家（发表主题演讲），如 是初级和中级科学家，我们有10个从提交的摘要中邀请演讲的名额。发言者 来自学术界，工业界和NIH，代表19个国家，将分享他们的最新发现， 九场会议：主旨会议一：氧自由基：将化学与生物学和医学联系起来; 线粒体从能量发电站到代谢调节器;干细胞功能中的氧自由基， 衰老和老化;氧化还原转化：治疗学的障碍和前进方向;内质网 疾病中蛋白质稳态和失调的网状氧化还原控制;死亡、稳态和代谢中的反应性脂质 作为治疗剂：铁蛋白沉着症及其他;氧化还原传感器、探针和诊断的进展;氧自由基 主旨会议二：氧自由基研究的技术进展; 挑战其他会议亮点是电力小时和代表妇女与twitter饲料 #REDOXWOMEN，并保证至少40%的演讲者或讨论领导者是女性。我们将 有电梯间距会议，以突出海报，并由学员的第一个问题的政策。我们将欢迎 表和社会活动，以包容新的与会者，并继续铁螺栓奖的传统， 最值得注意的评论。总的来说，这个计划将确保一个充满活力和合议的气氛，分享 氧自由基研究的最新发现，它们与疾病和衰老的关系，以及 治疗发展

Project Summary This conference grant proposal seeks funds for a Gordon Research Conference (GRC) on Oxygen Radicals: Chemical Reactivity, Metabolism, and Opportunities for Therapeutic Development to be held in Ventura CA February 2-7, 2020, in conjunction with a Gordon Research Seminar (GRS) for trainees, organized by two trainees (Cheryl van de Wetering, and Rhea Bovee), to be held immediate prior to the GRC, February 1-2, 2020 at the same location. We present an exciting program that brings together diverse fields of oxidant research, integrating recent discoveries of new oxidant species, with methodological advances, studies of biology, organelle dysfunction and metabolism, and aging, and plenary and round table discussions focusing on redox- based drugs in clinical development. The program includes senior scientists (giving the keynote lectures), as was as junior and mid-career scientists, and we have 10 slots for invited talks from submitted abstracts. Speakers are from academia, industry and the NIH, represent 19 countries and will be sharing their latest discoveries in nine sessions: Keynote session I: Oxygen Radicals: connecting chemistry with biology and medicine; Mitochondria from energy power houses to metabolite regulators; Oxygen radicals in stem cell function, senescence and aging; Redox in translation: Hurdles and ways forward toward therapeutics; Endoplasmic reticulum-redox control of proteostasis and dysregulation in disease; Reactive lipids in death, homeostasis and as therapeutics: Ferroptosis, and beyond; Advances in redox sensors, probes, and diagnostics; Oxygen radicals in metabolism; Keynote session II: Technical advances in the study of oxygen radicals; opportunities and challenges. Other conference highlights are the power hour and representation by women with a twitter feed #REDOXWOMEN and assurance that at least 40% of all presenters or discussion leaders are women. We will have elevator pitch sessions to highlight posters, and a policy of first questions by trainees. We will have welcome tables and social events to be inclusive of new attendees and continue the tradition of the Iron Bolt Award for the most notable comment. Collectively, this program will ensure a vibrant and collegial atmosphere to share the top discoveries in research on oxygen radicals, their involvement in disease and aging and potential avenues for therapeutic development.