Epidemiology, Immunopathogenesis, and Outcomes of Non-traumatic Spinal Cord Injury in Uganda

我的职业目标是成为一名神经炎症性疾病领域的独立研究员 乌干达。各种神经炎症性疾病在乌干达很常见，但这些疾病很少见。 明白了。乌干达只有几个训练有素的神经学家，很少有研究人员专注于 了解神经性疾病。因此，这一领域的专门知识存在很大差距，我希望 通过K43计划发展我的事业，通过获得我可以应用于调查的专业知识来填补这一空白 乌干达神经炎性疾病的流行病学和发病机制。 这个K43奖项将为我提供完成以下目标所需的支持： 1.设计和实施亚临床神经系统疾病的流行病学研究和临床试验 撒哈拉非洲。了解神经系统疾病的流行病学并设计干预措施 改善神经科患者的护理，我将需要额外的培训和相关经验 流行病学和生物统计学以及临床试验的设计和执行。 2.中枢神经系统炎症和感染。了解病原学和 神经炎的发病机制，我需要额外的培训和与神经学相关的经验 临床评估、中枢神经系统感染和神经炎症。 3.翻译与实施研究 在我未来的职业生涯中，我的目标是在基础科学研究和临床应用之间架起一座桥梁。这次培训 当我开发新的项目时，经验将帮助我将发现从长凳上翻译到床边，然后再翻译回来 随着我事业的发展。我也有兴趣学习如何将循证干预转化为 去实践和制定政策。 我已经组建了一个导师团队，由以下人员组成：主要研究导师--Boulware博士 和Meya博士(免疫学、传染病)和Dr。 Bohjanen(微生物学和免疫学，传染病)，Meyer博士(神经学，流行病学 神经系统疾病)Katabira教授(艾滋病毒感染的神经学)和Andrew Kambugu博士(传染性 疾病、临床研究)。 为了这个k43奖项，我将研究非创伤性脊髓的流行病学、病因和发病机制。 受伤。我将寻求：(1)。确定乌干达非创伤性脊髓损伤(SCI)的病因，(2) 确定特发性横贯性脊髓炎的脑脊液免疫征象是否可以根据 已知的急性横贯性脊髓炎的感染性病因。(3)确定人口学、临床学和 非创伤性脊髓损伤(SCI)患者预后不良的免疫学预测因素。 这个项目将作为K奖结束前R01申请的基础。

My career goal is to become an independent investigator in the field of neuroinflammatory disorders in Uganda. A variety of neuroinflammatory disorders are common in Uganda, but these disorders are poorly understood. There are only a handful of trained neurologists in Uganda and very few researchers focusing on understanding neurological disorders. Thus, there is a major gap in expertise in this area, and I wish to develop my career to fill this gap through this K43 program by gaining expertise that I can apply to investigating the epidemiology and pathogenesis of neuroinflammatory conditions in Uganda. This K43Award will provide me the support necessary to complete the following goals: 1. Design and execution of Epidemiological studies and clinical trials of neurological conditions in Sub- Saharan Africa. To understand the epidemiology of neurological conditions and design interventions for improving care among neurology patients, I will need additional training and experience related to epidemiology and biostatistics and in design and execution of clinical trials. 2. Neuroinflammation and infections of the central nervous system. To understand the etiology and pathogenesis of neuroinflammation, I will need additional training and experience related to neurological clinical assessments, infections of the central nervous system and neuroinflammation. 3. Translational and implementation research In my future career, I aim to bridge basic science research to clinical application and back. This training and experience will help me to translate findings from bench to bedside and back as I develop new projects as my career develops. I would also be interested in learning how to translate evidence based interventions to practice and policy. I have assembled a team of mentors comprising of the following: primary research mentors-Drs.Boulware (epidemiology and biostatics, infectious diseases) and Dr. Meya (immunology, infectious diseases), and Dr. Bohjanen (microbiology and immunology, infectious diseases) ,Dr. Meyer (neurology, epidemiology of neurological conditions) Prof. Katabira (neurology in HIV infection) and Dr Andrew Kambugu (infectious diseases, clinical research). For this k43 award, I will investigate epidemiology, etiology and pathogenesis of non-traumatic spinal cord injury. I will seek to: (1).To define the etiologies of non-traumatic spinal cord injury (SCI) in Uganda, (2) To determine if the CSF immune signature of idiopathic transverse myelitis can be grouped according to the known infectious etiologies of acute transverse myelitis. (3) To determine the demographic, clinical, and immunologic predictors of poor outcome among individuals with non-traumatic spinal cord injury (SCI). This project will serve as a basis for an R01 application before the end of the K award.