Mentoring and Neuroimaging Research on White Matter Pathology in Schizophrenia

摘要 我是一名临床放射科医生和训练有素的神经学家。我致力于我的研究 对脑白质病理的机制、性质和时间进程的理解 精神分裂症。我是放射科和精神科的副教授 在布里格姆妇女医院，哈佛医学院。我还担任助理 BWH精神病学系精神病学神经影像实验室主任 作为精神病学系形态测量分析中心的联席主任， 马萨诸塞州综合医院，我在那里有一个次要的研究职位 科学家。自2003年以来，我一直在进行一项由NIH赞助的研究，当时我 获得了我的第一个R03奖。我目前是NIMH R01奖的PI，专注于 新的神经影像生物标记物的风险、发病和转归 精神分裂症。我也是NIA资助的R01关于了解 通过一套神经成像工具和他们的大脑发育、成熟和衰老 在恒河猴身上的验证。这两笔赠款加在一起有可能提供 经过验证的神经成像生物标志物，可用于诊断和监测 精神分裂症髓鞘丢失和神经炎症所致的神经生物学改变 衰老，以及这些变化所在的其他神经精神疾病的完整清单 牵涉其中。除了我的研究，我还参与了哈佛、麻省理工学院和波士顿大学的指导工作 本科生和研究生论文学生，博士后研究员(包括T32和 K23获奖者)、外国研究员和暑期学生。我还参与了 行政工作，作为BWH和MGH两个大型实验室的负责人，以及各种 地方和区域委员会。最后，我将参与非临床和非POR 研究(通过我正在进行和即将进行的动物项目)，这从 我的导师和我的POR研究。K24会保护时间，并帮助我 专注于对我的职业发展最重要的工作-指导(30%)，进一步培训 和新的POR(20%)，同时将剩余50%投入正在进行的神经成像研究 在衰老和精神分裂症中脑白质变化的生物标志物中。

Abstract I am a clinical radiologist and neuroscientist by training. I have devoted my research career to understand mechanisms, nature and time-course of white matter pathology in schizophrenia. I am an Associate Professor in Departments of Radiology and Psychiatry at Brigham and Women’s Hospital, Harvard Medical School. I also serve as Associate Director of Psychiatry Neuroimaging Laboratory, Department of Psychiatry at BWH, and as a co-Director of Center for Morphometric Analysis, Department of Psychiatry, and Massachusetts General Hospital, where I have a secondary appointment as research scientist. I have been conducting an NIH sponsored research since 2003, when I received my first R03 award. I am currently PI on an NIMH R01 award, focusing on Development of New Neuroimaging Biomarkers of Risk, Onset and Outcome of Schizophrenia. I am also a PI on NIA funded R01 on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in schizophrenia, aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate thesis students, postdoctoral fellows (including T32 and K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at BWH and at MGH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and schizophrenia.