PC 重塑对巨噬细胞和脂肪细胞的影响：其与动脉粥样硬化的相关性-猫眼课题宝

PC 重塑对巨噬细胞和脂肪细胞的影响：其与动脉粥样硬化的相关性

批准号：

9914073

负责人：

XIAN-CHENG JIANG

金额：

$40.38万

依托单位：

SUNY DOWNSTATE MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-07-01 至 2022-04-30

来源：

https://reporter.nih.gov/project-details/9914073

关键词：

1-Phosphatidylinositol 3-Kinase Acyltransferase Adipocytes Adipose tissue Antiatherogenic Arterial Fatty Streak Atherosclerosis Body Weight CD80 gene Caveolae Cell membrane Cells Cellular Structures Chronic Clinical Closure by clamp Coculture Techniques Defect Development Diet Disease Dyslipidemias Fatty Acids Foam Cells Glucose Hematopoietic High Fat Diet ITGAM gene Immune Impairment Infiltration Inflammation Inflammatory Inflammatory Response Insulin Insulin Receptor Insulin Resistance Interleukin-6 Knockout Mice Lead Lecithin Link Lipids Lipolysis Lipopolysaccharides Low Density Lipoprotein Receptor Lysophosphatidylcholines Mediating Membrane Membrane Lipids Membrane Structure and Function Metabolic Metabolic Diseases Mitogen-Activated Protein Kinases Mus Myeloid Cells Non-Insulin-Dependent Diabetes Mellitus Nonesterified Fatty Acids Obesity Outcome Study PLA2G6 gene Palmitates Pathology Pathway interactions Peritoneal Phenotype Plasma Polyunsaturated Fatty Acids Positioning Attribute Process Production Protein Family Protein Isoforms Proto-Oncogene Proteins c-akt Reaction Regulation Saturated Fatty Acids Signal Transduction System TLR4 gene TNF gene Testing Triglycerides Visceral base cell type chemokine cytokine deacylation glucose disposal glucose metabolism glucose tolerance glucose uptake inflammatory marker insulin sensitivity insulin signaling insulin tolerance knock-down knockout gene macrophage metabolic phenotype novel overexpression polyunsaturated phosphatidylcholine prevent protein-tyrosine kinase c-src receptor recruit subcutaneous

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中文摘要

翻译

磷脂酰胆碱（PC）是细胞膜的主要成分，在细胞膜中从头合成。 Kennedy途径，然后通过Lands循环进行广泛的脱酰-再酰化重塑（非- Kennedy pathway）。再酰化由溶血磷脂酰胆碱酰基转移酶（LPCAT）催化，在Sn-2位添加多不饱和脂肪酸。多不饱和PC含量影响血浆膜的结构和功能到目前为止，已经描述了四种LPCAT亚型，我们确定 LPCAT 3是巨噬细胞和脂肪细胞中的主要亚型。在这里，我们假设，作为Lpcat 3缺乏的结果，巨噬细胞质膜中的饱和PC促进通过激活NFκB和MAP激酶信号传导，全身性胰岛素抵抗和动脉粥样硬化（目的1和2）。脂肪细胞中的Lpcat 3缺陷可能会钝化胰岛素信号传导，从而加速炎症、全身性胰岛素抵抗和动脉粥样硬化（Aim 3）。 Lpcat 3过表达应该具有相反的效果。这项研究的结果可能会导致一种新的抗- 临床使用的致动脉粥样硬化策略。

英文摘要

Phosphatidylcholine (PC) is the major component of cell membranes and is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands' cycle (non- Kennedy pathway). The reacylation is catalyzed by lysophosphatidylcholine acyltransferase (LPCAT), which adds a polyunsaturated fatty acid at the sn-2 position. Polyunsaturated PC content influences plasma membrane structure and function. Four LPCAT isoforms have been described to date, and we determined that LPCAT3 is the major isoform in macrophages and adipocytes. Here, we hypothesize that an increase in saturated PCs in the plasma membrane of macrophages, as a consequence of Lpcat3 deficiency, promotes inflammation by activating NFκB and MAP kinase signaling and promotes inflammation-induced systemic insulin resistance and atherosclerosis (Aims 1 and 2). Lpcat3 deficiency in adipocytes might blunt insulin signaling, thereby accelerating inflammation, systemic insulin resistance and atherosclerosis (Aim 3). Lpcat3 overexpression should have the opposite effects. The outcomes of this study could lead to a novel anti- atherogenic strategy for clinical use.

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