SETAC North America Non-Target Analysis in Environmental Risk Assessment Focus Topic Meeting

SETAC北美专题会议 环境综合评价中的非目标分析 达勒姆会议中心，美国北卡罗来纳州达勒姆 2020年5月26日至31日 项目摘要 NIEHS为SETAC北美专题会议寻求NIEHS支持 综合环评分析.会议的首要任务是推进 涉及高通量识别、科学研究和监管的子学科 环境和生物介质中与人类和生态系统健康有关的化学品。 会议将召集专家报告该领域的最新进展，并确定重要的 妨碍广泛实施和使用非目标分析的研究需要 结果。 为了实现拟议会议的目标，我们将实现以下具体目标： 1.为来自不同学科的专业人士提供论坛(包括数据科学和 统计学、(生态)毒理学、分析和环境化学、化学信息学、 暴露、毒性和风险评估)和来自多个背景(学术界、 行业、政府和非营利组织)齐聚一堂，讨论和 提升该领域的知识水平； 2.开发非目标分析中化合物识别优先顺序的框架 环境和生物样本； 3.提出分析和数据分析、业绩和出版的基准； 4.查明与可重复获得有关的知识差距和不足之处， 报告和存档非目标分析实验产生的数据； 5.严格评估在以下方面使用非目标分析的优点和实际限制 环境监测、暴露组学研究和化学风险评估。 这些目标将通过召集不同研究领域的领先国际专家来实现， 工作活动和组织。通过这项赠款申请寻求的资金将用于 以抵消12名受邀专家的出席费用，并包括注册费和 旅行津贴。这次会议将持续五天，包括讲台和 海报会议、分组讨论、小组讨论和工具演示，预计 吸引了200名专家。 会议技术方案将涵盖四个主要议题： 1.非目标分析的科学状况：仪器、数据评估、监测 应用程序 2.确定未知因素的优先顺序：新的分析物、转化产品和 代谢物 3.数据分析和其他工具：统计、暴露、毒性、建模 4.展望未来：基准、知识差距和广泛实施 会议成果包括至少一篇同行评议的期刊文章，以总结 -科学，并捕捉讨论和想法。我们还希望在期刊上发表一篇文章 来自主持人提交的关于该主题的系列文章。此外，海报和幻灯片图像来自 会议演示文稿将存档。

SETAC North America Focused Topic Meeting Non-Targeted Analysis for Comprehensive Environmental Assessment Durham Convention Center, Durham, North Carolina, USA May 26-31, 2020 Project Summary NIEHS support is sought for the SETAC North America Focused Topic Meeting “Non-Targeted Analysis for Comprehensive Environmental Assessment.” The meeting priority is to advance sub-disciplines involved in high-throughput identification, scientific study, and regulation of chemicals in environmental and biological media relevant to human and ecosystem health. The meeting will gather experts to report on recent advances in the field and identify significant research needs hindering the wide-spread implementation and use of non-targeted analysis results. To meet the proposed meeting’s objectives, we will pursue the following specific goals: 1. Provide a forum for professionals from different disciplines (including data science and statistics, (eco-)toxicology, analytical and environmental chemistry, cheminformatics, exposure, toxicity, and risk assessment) and from many backgrounds (academia, industry, government, and non-profit organizations) to come together to discuss and advance the state of the knowledge in the field; 2. Develop a framework for compound identification prioritization in non-targeted analysis of environmental and biological samples; 3. Propose benchmarks for analytical and data analyses, performance, and publication; 4. Identify knowledge gaps and shortcomings related to the reproducible acquisition, reporting and archiving of data generated by non-targeted analysis experiments; 5. Critically assess strengths and practical limitations of using non-targeted analysis in environmental monitoring, exposomics research, and chemical risk assessment. These goals will be achieved by convening leading international experts diverse research fields, job activities, and organizations. Funds being sought through this grant application will be used to offset the cost of the attendance for 12 invited experts and to include registration fees and a travel stipend. The meeting will span five days consisting of a combination of platform and poster sessions, breakout groups, panel discussions, and tool demonstrations, and is expected to attract 200 experts. The meeting technical program will cover four main topics: 1. State of the science in non-targeted analysis: instrumentation, data evaluation, monitoring application 2. Prioritizing unknowns for identification: new analytes, transformation products and metabolites 3. Tools for data analysis and beyond: statistics, exposure, toxicity, modeling 4. Looking ahead: benchmarks, knowledge gaps, and wide-spread implementation Meeting outcomes include at least one peer-reviewed journal article to summarize the state-of- the-science and capture discussions and ideas. We also expect to develop a journal article series on the topic from submissions by presenters. Further, poster and slide images from meeting presentation will be archived.