Skeletal Disorders Training Program

 描述(由申请人提供)：华盛顿大学医学院及其附属巴恩斯-犹太医院在肌肉骨骼研究、患者护理、教育和培训方面拥有40年的卓越传统。2011年，华盛顿大学代谢性骨骼疾病培训项目(T32)在Roberto Civitelli博士的领导下成立，旨在培训下一代骨骼研究人员和医生。2012年1月，通过内科(骨和矿物病科)和整形外科之间的伙伴关系以及医学院院长的支持，将T32活动与Linda Sandell博士指导的肌肉骨骼生物学和医学核心中心(P30)的活动整合为一个新的肌肉骨骼研究中心。MRC将T32和P30的互补目标整合到一个统一的结构中，使我们中心的资源得到有效利用，并在研究和教育任务之间实现协同。这个T32，此后被命名为骨骼疾病培训计划(SDTP)，提供3个博士后和3个博士后职位，在资助的前4年，总共有10名学员(4名研究生和6名博士后学员)进入该项目。其中，两名博士后实习生获得了教职任命，一名获得了K99/R00奖学金；另一名西班牙裔美国人获得了F32奖学金。在4名博士后实习生中，1人已毕业并开始博士后培训，1人正在攻读医学博士/博士学位。他们总共发表了28篇同行评议的手稿，并获得了无数的奖项和认可。SDTP提供5个主题领域的研究培训，反映了参与培训计划的教师的重点和共同兴趣：1)骨骼的系统和局部调节；2)骨骼免疫学；3)肿瘤-骨骼相互作用；4)骨骼的遗传学和发育；5)骨骼生物力学和修复。本次SDTP的导师来自华盛顿大学的9个学术部门。培训包括5个部分：1)指导性研究培训；2)课程作业；3)丰富活动；4)职业发展；5)负责任的研究行为。博士前培训计划与生物和生物医学科学部(DBBS)和生物医学工程系(BME)管理的博士和医学/博士课程整合在一起。T32建立在强有力的跨部门和全校支持的基础上，并利用了MRC核心和基础设施以及其他机构资源，例如DBBS和BME部门(用于实习生招聘和课程工作)，以及翻译和临床科学研究所(用于额外的核心、服务和职业发展培训)。在当前的资助周期中引入的具体新增内容和未来提出的创新建议包括，将BME学生纳入博士前人才库，将导师人才库扩大到对癌症生物学感兴趣的教职员工，扩大教育课程和丰富活动，以及加强职业发展教育。培训下一代医生和科学家对于骨骼生物学研究的持续增长至关重要。这种研究对于了解骨骼疾病的遗传和分子基础以及设计新的治疗策略是必要的，这些疾病包括骨质疏松症、炎症性骨溶解、骨关节炎、肌腱衰竭和骨转移，这些疾病对 老年人口的比例。

 DESCRIPTION (provided by applicant): Washington University School of Medicine and the affiliated Barnes-Jewish Hospital have a 40-year tradition of excellence in musculoskeletal research, patient care, education and training. In 2011, the Washington University Metabolic Skeletal Disorders Training Program (T32) was established under the leadership of Dr. Roberto Civitelli, with the purpose of training the next generation of skeletal investigators and physician. In January 2012, T32 activities were integrated with those of the Core Center for Musculoskeletal Biology and Medicine (P30), directed by Dr. Linda Sandell, into a new Musculoskeletal Research Center (MRC), through a partnership between the Departments of Internal Medicine (Division of Bone and Mineral Diseases) and Orthopaedic Surgery, and support by the Dean of the Medical School. The MRC integrates the complementary aims of this T32 and the P30 into a unified structure that allows efficient utilization of the resources and synergism between the research and education missions of our Center. This T32, henceforth named Skeletal Disorders Training Program (SDTP), offers 3 pre- and 3 post-doctoral positions, and in the first 4 years of funding, a total of 10 trainees (4 graduate students and 6 post-doctora trainees) have entered the program. Of these, two post-doctoral trainees have obtained faculty appointments, one has been awarded a K99/R00 grant; another one, a Hispanic-American, obtained a F32 fellowship. Of the 4 pre- doctoral trainees, one has graduated and started post-doctoral training, and one is pursuing a combined M.D/Ph.D. degree. Together, they have published 28 peer-reviewed manuscripts and received numerous awards and recognitions. This SDTP offers research training in 5 thematic areas, reflecting the focus and common interests of the faculty participating in this training program: 1) Systemic and Local Regulation of the Skeleton; 2) Skeletal Immunology; 3) Tumor- Skeleton Interactions; 4) Genetics and Development of the Skeleton; 5) Skeletal Biomechanics and Repair. Mentors selected for this SDTP are drawn from 9 academic Departments at Washington University. The training consists of 5 components: 1) mentored research training; 2) curriculum coursework; 3) enrichment activities; 4) career development; 5) responsible conduct of research. The pre-doctoral training program is integrated with the PhD and MD/PhD programs administered by the Division of Biology and Biomedical Sciences (DBBS) and the Department of Biomedical Engineering (BME). This T32 builds on strong interdepartmental and School-wide support, and leverages the MRC Cores and infrastructure and other institutional resources, such as the DBBS and BME Department (for trainee recruitment and coursework), and the Institute for Translational and Clinical Sciences (for additional cores, services and career development training). Specific additions introduced during the current funding cycle and innovations proposed going forward are, among others, inclusion of BME students to the pre- doctoral pool, expansion of the mentor pool to faculty with interest in cancer biology, broadening of the educational coursework and enrichment activities, and strengthening career development education. Training the next generation of physicians and scientists is paramount to the continuous growth of research on skeletal biology. Such research is necessary to understand the genetic and molecular bases of skeletal disorders and to devise new treatment strategies for diseases such as osteoporosis, inflammatory osteolysis, osteoarthritis, tendon failure, and bone metastasis, which afflict a large proportion of the elderly population.