Cluster C: 8 Tissue Procurement

组织采购核心(TPC)协助HCCC成员收集、存储和分发 恶性和非恶性人体生物材料。TPC的总体目标是为HCCC提供 成员使用符合IRB、临床注释、质量保证的生物材料，以促进他们的研究 目标，并保持对生物库最佳做法的前沿观点。它提供了 质量控制，IRB批准的1)新鲜和冷冻的肿瘤组织，2)癌症的血液和DNA样本 患者，以及3)福尔马林固定的石蜡包埋的癌症组织，来自病理和 爱荷华州残留组织储存库和虚拟组织储存库。TPC与其他HCCC单位合作，以 使用相关临床信息对样本进行注释，包括分子流行病学资源、 人口研究核心和临床试验支持办公室满足个人HCCC的需求 从事基础、转化性和基于人群的癌症研究的成员和团体。在……里面 此外，TPC还向癌症等国家活动提供了有质量保证的组织资源 基因组图谱(TCGA)计划和NCI患者来源的异种移植(PDX)计划。TPC是一个完整的 通过主要机构UI BioShare与更广泛的卡弗医学院生物库合作 已作出重大投资以提供全机构生物材料数据库的倡议 管理工具，并实现生物材料与临床数据之间的有效连接 医疗记录保存在UIHC EPIC信息系统中。2014年，TPC从 为HCCC提供了552例，并向所有4个项目的HCCC成员分发了865种生物材料。

The Tissue Procurement Core (TPC) assists HCCC members in the collection, storage, and distribution of malignant and non-malignant human biomaterials. The overarching goal of the TPC is to provide HCCC members with IRB-compliant, clinically annotated, quality-ensured biomaterials to facilitate their research objectives and to maintain a cutting-edge perspective on biobanking best practices for the HCCC. It provides quality-controlled, IRB-approved 1) fresh and frozen tumor tissue, 2) blood and DNA samples from cancer patients, and 3) formalin-fixed paraffin-embedded cancer tissue from the Department of Pathology and the Iowa Residual Tissue Repository and Virtual Tissue Repository. The TPC works with other HCCC units to annotate samples with relevant clinical information including the Molecular Epidemiology Resource, the Population Research Core and the Clinical Trials Support Office to meet the needs of individual HCCC members and groups conducting basic, translational and population-based cancer research studies. In addition, the TPC has supplied quality-ensured tissue resources to national efforts such as The Cancer Genome Atlas (TCGA) project and the NCI patient-derived xenograft (PDX) program. The TPC is integrally connected to broader Carver College of Medicine biobanking efforts through UI Bioshare, a major institutional initiative in which significant investment has been made to provide an institution-wide biomaterial database management tool and to enable the efficient connection of biomaterials to clinical data from the electronic medical record held in the UIHC EPIC information system. In 2014 the TPC collected biomaterials from 552 cases for the HCCC, and distributed 865 biomaterials to HCCC members from all 4 programs.