A New Paradigm for Treating Functional Abdominal Pain Disorders in Children

项目摘要 约翰·M·霍利尔，医学博士，委员会认证的儿科胃肠病专家，贝勒学院助理教授 寻求获得基本技能和为独立职业生涯提供指导的研究经验的医学博士 作为一名利用卫生技术的儿科临床研究人员。医学的许多方面都受到 服药依从性差，健康行为不明智，获得医疗保健的机会很少。候选人的 职业目标是通过利用当前(例如，移动)和未来的潜力来克服这些障碍 技术作为完成这些努力的工具。功能性腹痛障碍(FAPD)影响多达 全世界20%的学龄儿童(和成人)，并与严重的发病率和健康有关 护理费用。高达60%的患有FAPDS的儿童继续患有与成人类似的疾病。许多人受到影响 儿童遭受焦虑和抑郁等心理社会痛苦。对这些疾病最有效的治疗方法是 精神障碍(心理干预)对大多数FAPDS儿童来说仍然遥不可及。申请人 计划改进其创新的移动应用程序(App)原型，旨在远程交付音频- 采用公认技术的记录引导成像疗法(ARGIT App)治疗儿童FAPDS 开发技术。具体目标：1)完善我们的ARGIT应用原型的设计、运营和GIT 通过定性访谈，通过患者、护理人员和专家利益相关者的反馈提供会议内容2) 进行一项双盲随机对照试验，比较GIT和深呼吸练习(对照) 应用改良的ARGIT App在8周以上的FAPDS儿童中评估引导成像的效果 治疗并评估随着时间的推移，心理社会痛苦是否会因这种干预而改变。3) 评估改进的ARGIT应用程序在受影响儿童及其照顾者中的可接受性 定性访谈。Hollier博士组建了一个由受人尊敬的NIH资助的导师组成的多学科团队 以及在移动健康应用程序开发、临床试验方面拥有各种专业知识的协作者 方法论、定性研究方法和健康行为改变专家。此外， 应聘者将通过授课课程、研讨会、指导获得更多技能和培训 阅读材料和会议。通过这笔赠款获得的科学培训将导致出版物、数据、 和经验，使候选人能够获得NIH的资金，并确立自己作为一个独立的 内科科学家。

Project Abstract John M. Hollier, MD, a board-certified pediatric gastroenterologist, is an Assistant Professor at Baylor College of Medicine who seeks to obtain essential skills and mentored research experience for an independent career as a pediatric clinical researcher utilizing health technologies. Many aspects of medicine are affected by poor medication adherence, ill-advised health behaviors, and poor access to medical care. The candidate’s career goal is to conquer these barriers by harnessing the potential of current (e.g., mobile) and future technologies as tools to fulfill these endeavors. Functional abdominal pain disorders (FAPDs) affect up to 20% of school-age children (and adults) worldwide and are associated with significant morbidity and health care costs. Up to 60% of children with FAPDs go on to have similar conditions as adults. Many affected children suffer from psychosocial distress like anxiety and depression. The most effective treatment for these disorders (psychological interventions) remains out of reach for most children with FAPDs. The applicant proposes to refine his innovative mobile application (App) prototype designed to remotely deliver audio- recorded guided imagery therapy (ARGIT App) for pediatric patients with FAPDs using accepted technology development techniques. Specific Aims: 1) Refine our ARGIT App prototype’s design, operation, and GIT session content via patient, caregiver, and expert stakeholders’ feedback by using qualitative interviews 2) Conduct a double-blind, randomized controlled trial comparing GIT versus deep breathing exercises (control) utilizing the refined ARGIT App over 8 weeks in children with FAPDs to assess the efficacy of guided imagery therapy and evaluate whether psychosocial distress is altered as a result of this intervention over time. 3) Assess acceptability of the refined ARGIT App among affected children and their caregivers through qualitative interviews. Dr. Hollier has assembled a multidisciplinary team of esteemed NIH-funded mentors and collaborators with a diverse range of expertise in mobile health App development, clinical trial methodology, qualitative research methods, and health behavior change specialists. In addition, the candidate will acquire additional skills and training through didactic coursework, workshops, directed readings, and conferences. The scientific training obtained through this grant will lead to publications, data, and experience that will enable the candidate to secure NIH funding and establish himself as an independent physician scientist.