A Dyadic Sleep Intervention for Alzheimers Disease Patients and Their Caregivers

项目摘要/摘要 宋延秀，博士，RN，FNP-C是加州大学洛杉矶分校大卫·格芬医学院的助理教授， 完全致力于成为一名独立资助的研究人员，专门研究患有睡眠障碍的个人 认知障碍，如阿尔茨海默病(AD)及其照顾者。她特别感兴趣的是 为阿尔茨海默病患者和他们的非正式照顾者测试一项二元睡眠干预计划。Dr。 宋的独特背景使她成为这一研究领域的理想人选。她接受过奖学金培训。 拥有高级老年医学学位，并拥有高级护理执业资格证书，成为家庭护理从业者。 她目前通过退伍军人事务部(VA)大中华区得到老年医学高级研究员的支持 洛杉矶医疗保健系统，老年研究，教育和临床中心(GRECC)。 职业发展和培训计划：该计划的特点是突出的研究和教育 在加州大学洛杉矶分校的环境，由全国知名的专家导师。她的主要指导团队由以下人员组成 Jennifer Martin博士(行为睡眠干预专家)，Cathy Alessi博士(睡眠医学专家)，Michael Irwin(炎症因子和睡眠专家)和Edmond Teng(AD评估专家)。她还会 利用加州大学洛杉矶分校的CTSI、加州大学洛杉矶分校的老年医学多校园计划和 老年学、加州大学洛杉矶分校的克劳德·D·佩珀中心和GRECC。她的训练计划以精心策划为特色 课程作业和实践培训经验，都与她的培训目标一致。 研究计划：拟议的研究是以假设为导向的，并以宋博士的初步数据为指导 退伍军人事务部资助的先导研究和现有的行为睡眠干预方法。在她过去的两年里 作为团契成员，她开发了一个二元睡眠干预计划。在阶段1(目标1)中，她将反复 通过以下方式完善并最终确定针对双方成员(患者和照顾者)的干预计划 评估可接受性和可用性。在第二阶段(目标2-4)，她将通过评估来试行该计划的效果 采用一项小型随机对照试验设计，对两组成员的睡眠、健康和生活质量进行研究。 主要的分析集中在照顾者的结果上。干预计划将包括五个疗程， 包括4次家访和1次电话会议。它将包括人工睡眠卫生建议 以及包括睡眠压缩疗法在内的行为睡眠干预。建议中的一个独特方面 工作是，该计划是为解决患者和照顾者的睡眠问题而量身定做的，包括 上游生物标记物用于评估干预益处的关键机制，可在 未来的研究。通过执行此培训和研究计划发展起来的技能将使宋博士能够 成为AD患者睡眠管理研究的独立研究员和领导者 照顾者，目标是改善他们的健康和生活质量。

Project Summary/Abstract Yeonsu Song, PhD, RN, FNP-C is an Assistant Professor at the David Geffen School of Medicine at UCLA and is fully committed to becoming an independently-funded investigator specializing in sleep in individuals with cognitive impairments such as Alzheimer’s disease (AD) and their caregivers. She has a particular interest in testing a dyadic sleep intervention program for Alzheimer’s disease patients and their informal caregivers. Dr. Song’s unique background makes her an ideal candidate for this field of research. She has fellowship training in advanced geriatrics, and has board certification in advanced practice nursing as a family nurse practitioner. She is currently supported by an Advanced Fellowship in Geriatrics through the Veterans Affairs (VA) Greater Los Angeles Healthcare System, Geriatric Research, Education, and Clinical Center (GRECC). Career development and training plan: This plan features an outstanding research and educational environment at UCLA, with nationally renowned expert mentors. Her primary mentoring team is comprised of Drs. Jennifer Martin (expert in behavioral sleep interventions), Cathy Alessi (expert in sleep medicine), Michael Irwin (expert in inflammatory factors and sleep), and Edmond Teng (expert in assessment of AD). She will also draw on resources available through UCLA’s CTSI, UCLA’s Multicampus Program in Geriatric Medicine and Gerontology, UCLA’s Claude D. Pepper Center, and the GRECC. Her training plan features carefully curated coursework and hands-on training experiences, all aligned with her training goals. Research plan: The proposed research is hypothesis-driven and guided by preliminary data from Dr. Song’s VA-funded pilot study and existing behavioral sleep intervention methods. During the past 2 years of her fellowship, she has developed a dyadic sleep intervention program. In phase 1 (Aim 1), she will iteratively refine and finalize the intervention program targeting both members of the dyad (patients and caregivers) by evaluating acceptability and usability. In phase 2 (Aims 2-4) she will pilot test the program effects by assessing sleep, health, and quality of life in both members of the group using a small randomized controlled trial design, with the main analyses focused on caregiver outcomes. The intervention program will involve five sessions, including 4 home visits and one telephone session. It will include manualized sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy. A unique aspect of the proposed work is that the program is tailored to address sleep problems of both patients and caregivers, and includes upstream biomarkers to evaluate a key mechanism of intervention benefits that can be further explored in future research. Skills developed from executing this training and research plan will enable Dr. Song to become an independent researcher and a leader in research on managing sleep in AD patients and their caregivers, with the goal of improving their health and quality of life.