A Dyadic Sleep Intervention for Alzheimer's Disease Patients and Their Caregivers

针对阿尔茨海默病患者及其护理人员的二元睡眠干预

• 批准号: 10598370
• 负责人: Yeonsu Song
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598370
• 关键词: Address; Admission activity; Aftercare; Alzheimer' s Disease; Alzheimer' s disease caregiver; Alzheimer' s disease patient; American; Appointment; Area; Award; Behavioral; Biological Markers; Biological Process; C-reactive protein; COVID-19 pandemic; Cardiovascular system; Caregivers; Chronic Disease; Cognitive; Control Groups; Data; Dementia; Doctor of Philosophy; Education; Ensure; Event; Focus Groups; Funding; Future; Gene Expression; Genomics; Goals; Health; Health Care Costs; Hour; Hypertension; Impaired cognition; Individual; Inflammation; Inflammatory; Institution; Institutionalization; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Measures; Medicine; Mentors; Methods; Modality; Nature; Non-Insulin-Dependent Diabetes Mellitus; Nursing Homes; Outcome; Patient Care; Patients; Persons; Preparation; Public Health; Quality of Care; Quality of life; Randomized; Randomized Controlled Trials; Recommendation; Research; Research Activity; Research Personnel; Research Training; Resources; Risk; School Nursing; Sleep; Sleep Disorders; Sleep disturbances; Stress; Structure; Techniques; Testing; Time; Training; Training Activity; United States National Institutes of Health; Work; actigraphy; base; career development; caregiver interventions; community setting; compression therapy; economic value; experience; follow-up; improved; improvement on sleep; inflammatory marker; informal caregiver; innovation; interest; intervention effect; intervention program; medical schools; meetings; member; mortality risk; novel; pilot test; poor sleep; prevent; primary outcome; professor; programs; recruit; research study; skill acquisition; skills; sleep difficulty; sleep health; sleep quality; telehealth; trial design; usability; virtual

Project Summary/Abstract Yeonsu Song, PhD, RN, FNP-C is an Assistant Professor at School of Nursing at UCLA with join appointment at David Geffen School of Medicine. She is fully committed to becoming an independently funded investigator specializing in sleep in individuals with cognitive impairments such as Alzheimer’s disease (AD) and their caregivers. She has a particular interest in testing a dyadic sleep intervention program for AD patients and their informal caregivers. Career development and training plan: During this 1-year extended K award, Dr. Song will continue to work with her mentors to complete training activities disrupted by the COVID-19 pandemic related restrictions. Core training activities will include (1) refining skills necessary to deliver a dyadic sleep intervention program both in in-person and telehealth delivery modalities, (2) enhancing skills in recruitment, particularly using virtual strategies, (3) obtaining new knowledge of associations between inflammation and sleep among Alzheimer’s caregivers by analyzing her research study data, and (4) refining career development skills. The mentoring team is comprised of Drs. Jennifer Martin (expert in behavioral sleep interventions), Cathy Alessi (expert in sleep medicine), Michael Irwin (expert in inflammatory factors), and Edmond Teng (expert in assessment of AD). She will continue to draw on resources available at UCLA and the VAGLAHS. Her training plan features carefully curated coursework and hands-on training experiences, all aligned with her training goals. Research plan: This extended funding will ensure Dr. Song to successfully achieve all study aims as planned in her original proposal. In Stage 1A (Aim 1), she already iteratively refined and finalized the dyadic sleep intervention program targeting both members of the dyad (patients and caregivers). In Stage 1B (Aims 2-4), she has been pilot-testing the program effects by assessing sleep, health, and quality of life in both members of the group using a small randomized controlled trial design. The dyadic sleep intervention program consists of one hour, 5 weekly sessions, which include manualized sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy. A unique aspect of the proposed work is that the program is tailored to address sleep problems of both patients and caregivers, and includes upstream inflammatory biomarkers among caregivers to evaluate a key mechanism of intervention benefits that can be further explored in future research. Over the past years, she has randomized 25 dyads in this study. During the extended award, Dr. Song will randomize additional 15 dyads thus, analyze the data of 40 dyads. Skills developed from executing all training and research plan will enable Dr. Song to become an independent researcher and a leader in research on managing sleep in AD patients and their caregivers, with the goal of improving their health and quality of life.

项目摘要/摘要 宋延秀，博士，RN，FNP-C，加州大学洛杉矶分校护理学院助理教授，加盟 在大卫·格芬医学院。她完全致力于成为一名独立资助的调查员 专门研究认知障碍患者的睡眠，如阿尔茨海默病(AD)和他们的 照顾者。她对测试AD患者和他们的二元性睡眠干预计划特别感兴趣 非正式的照顾者。 职业发展和培训计划：在这个为期1年的延期K奖期间，宋博士将继续工作 与她的导师一起完成了因新冠肺炎疫情相关限制而中断的培训活动。堆芯 培训活动将包括(1)完善必要的技能，以提供两个方面的睡眠干预计划 面对面和远程保健提供方式，(2)加强招聘技能，特别是使用虚拟 策略，(3)获得阿尔茨海默氏症患者炎症和睡眠之间关系的新知识 通过分析她的研究学习数据，以及(4)提炼职业发展技能。指导工作 该团队由詹妮弗·马丁博士(行为睡眠干预专家)、凯西·阿莱西博士(睡眠干预专家)组成。 睡眠医学)、Michael Irwin(炎症因子专家)和Edmond Teng(评估 AD)。她将继续利用加州大学洛杉矶分校和VAGLAHS的可用资源。她的训练计划的特点是 精心策划的课程和实践培训经验，所有这些都与她的培训目标一致。 研究计划：这笔延长的资金将确保宋博士成功地按计划实现所有研究目标 在她最初的提议中。在阶段1A(目标1)，她已经反复改进和完成了二元睡眠 针对双方成员(患者和照顾者)的干预计划。在阶段1B(目标2-4)， 她一直在通过评估两个成员的睡眠、健康和生活质量来试行该计划的效果 采用一项小型随机对照试验设计。二元睡眠干预计划包括 每周5次，每次1小时，其中包括手动睡眠卫生建议和行为 睡眠干预，包括睡眠压缩疗法。拟议工作的一个独特方面是 计划是为解决患者和照顾者的睡眠问题而量身定做的，包括上游 在照顾者中评估干预益处的关键机制的炎性生物标记物 在未来的研究中进一步探索。在过去的几年里，她在这项研究中随机选择了25个二元体。在.期间 获奖后，宋博士将再随机抽取15个二联体，分析40个二联体的数据。技能 从执行所有培训和研究计划发展而来，将使宋博士成为一个独立的 研究人员和AD患者及其照顾者睡眠管理研究的领导者，目标是 改善他们的健康和生活质量。

项目成果

Sleep Outcomes With Cognitive Behavioral Therapy for Insomnia Are Similar Between Older Adults With Low vs. High Self-Reported Physical Activity.

• DOI: 10.3389/fnagi.2018.00274
• 发表时间: 2018
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Yeung T;Martin JL;Fung CH;Fiorentino L;Dzierzewski JM;Rodriguez Tapia JC;Song Y;Josephson K;Jouldjian S;Mitchell MN;Alessi C
• 通讯作者: Alessi C

Change in Dysfunctional Sleep-Related Beliefs is Associated with Changes in Sleep and Other Health Outcomes Among Older Veterans With Insomnia: Findings From a Randomized Controlled Trial.

与睡眠相关的功能失调信念的改变与失眠老年退伍军人的睡眠和其他健康结果的变化有关：随机对照试验的结果。

• DOI: 10.1093/abm/kaab030
• 发表时间: 2022
• 期刊: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
• 作者: Song,Yeonsu;Kelly,MonicaR;Fung,ConstanceH;Dzierzewski,JosephM;Grinberg,AustinM;Mitchell,MichaelN;Josephson,Karen;Martin,JenniferL;Alessi,CathyA
• 通讯作者: Alessi,CathyA

Sleep Disruption Due to Stress in Women Veterans: A Comparison between Caregivers and Noncaregivers.

女性退伍军人因压力而导致的睡眠中断：护理人员和非护理人员之间的比较。

• DOI: 10.1080/15402002.2020.1732981
• 发表时间: 2021
• 期刊: Behavioral sleep medicine
• 影响因子: 3.1
• 作者: Song,Yeonsu;Carlson,GwendolynC;McGowan,SarahKate;Fung,ConstanceH;Josephson,KarenR;Mitchell,MichaelN;McCurry,SusanM;Teng,Edmond;Irwin,MichaelR;Alessi,CathyA;Martin,JenniferL
• 通讯作者: Martin,JenniferL

Values Expressed by Women Veterans Receiving Treatment for Chronic Insomnia Disorder.

接受慢性失眠症治疗的女性退伍军人所表达的价值观。

• DOI: 10.1080/15402002.2023.2260517
• 发表时间: 2023
• 期刊: Behavioral sleep medicine
• 影响因子: 3.1
• 作者: Saldana,KathrynS;Carlson,GwendolynC;Revolorio,Kaddy;Kelly,MonicaR;Josephson,KarenR;Mitchell,MichaelN;Culver,Najwa;Kay,Morgan;McGowan,SarahKate;Song,Yeonsu;Deleeuw,Charles;Martin,JenniferL
• 通讯作者: Martin,JenniferL

Measuring Sleep in Vulnerable Older Adults: A Comparison of Subjective and Objective Sleep Measures.

• DOI: 10.1080/07317115.2017.1408734
• 发表时间: 2018-03
• 期刊: Clinical gerontologist
• 影响因子: 2.8
• 作者: Hughes JM;Song Y;Fung CH;Dzierzewski JM;Mitchell MN;Jouldjian S;Josephson KR;Alessi CA;Martin JL
• 通讯作者: Martin JL