Integrative Training in the Neurocircuitry of Affective Disorders

 描述（由申请人提供）：标题：情感障碍神经回路的综合培训拟议修订的机构国家研究服务奖培训计划将为基础和临床神经科学家提供技能和导师指导的经验，以推动他们进入跨学科的研究生涯，旨在进一步了解脑回路和影响。我们要求在第一年的两个职位和四个职位，每年随后的资金。应用于理解精神病理学的脑回路领域是一个快速增长的领域，具有很大的潜力，可以帮助理解情感性精神疾病的因果途径和机制。抑郁症和压力神经调节中心（CNDS）与宾夕法尼亚大学（PENN）的多个部门，中心和研究所合作，准备推出基于成像领域的创新以及拟议的多学科导师组提供的相关专业知识的新型博士后奖学金。拟议的培训认识到，了解脑电路病理学所需的工具需要跨精神病理学，人类神经成像方法，统计学，工程学，神经科学，遗传学和相关成像的基本转化模型（如光遗传学）的培训。该计划将由Yvette Sheline博士（抑郁症和压力的神经成像）指导。John Detre博士（临床神经科学和功能性神经成像方法开发）将担任副主任。他们加入了众多的研究人员在宾夕法尼亚州具有丰富的跟踪记录的经验，在成像的情感障碍，包括干部的研究人员在最前沿的新方法的发展;许多这些实验室将共同定位，沿着学员，在一个新的设施。使用神经科学模型对精神病理学进行脑回路方法的研究是一种新颖的训练方法。该计划导师提供了一个独特的多学科培训环境，在其中追求这种令人兴奋的新方法，鉴于神经影像学研究人员在医学的佩雷尔曼学校的临床和基础部门之间建立的合作，以及他们与生物医学研究生课程的接口。该大学在神经成像和转化神经科学前沿的作用提供了一个机会，帮助培养下一代年轻科学家，他们可以从核心心理学的角度，神经和翻译机制，可以告知和跨越精神病理学的传统界限，并导致更有效的治疗和新目标的识别为了预防。

 DESCRIPTION (provided by applicant):Title: Integrated Training in Neurocircuitry of Affective Disorders The proposed revised Institutional National Research Service Award Training Program will provide basic and clinical neuroscientists with the skills and mentor-guided experiences to propel them into an interdisciplinary research career designed to further the understanding of brain circuitry and affect. We request funds for two positions in Year 1 and four positions each subsequent year. The area of brain circuitry as applied to understanding psychopathology is a rapidly growing domain with great potential to inform the understanding of the causal pathways and mechanisms of affective mental illness. The Center for Neuromodulation in Depression and Stress (CNDS), in collaboration with multiple University of Pennsylvania (PENN) departments, centers and institutes is well poised to launch this novel post-doctoral fellowship based on established innovations in imaging, as well as the range of related expertise offered by the proposed multidisciplinary mentor group. The proposed training recognizes that the tools necessary to understand brain circuitry pathology require training across psychopathology, human neuroimaging methodology, statistics, engineering, neuroscience, genetics and basic translational models with associated imaging, such as optogenetics. The program will be guided by Dr. Yvette Sheline, (neuroimaging of depression and stress). Dr. John Detre (clinical neuroscience and methods development in functional neuroimaging) will be Associate Director. They are joined by numerous investigators at PENN with a rich track record of experience in imaging of affective disorders, including a cadre of investigators at the forefront of new methods development; many of these labs will be co-located, along with trainees, in a new facility. Research taking a brain circuit approach to psychopathology using a neuroscience model is a novel approach for training. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting new approach, given the established collaborations between neuroimaging researchers in the clinical and basic departments of the Perelman School of Medicine and their interface with the Biomedical Graduate Studies program. The University's role at the forefront of neuroimaging and translational neuroscience offers an opportunity to help train the next generation of young scientists who can pursue fundamental questions about abnormalities in brain circuitry in affective illness from the perspective of core psychological, neural and translational mechanisms that can inform and span traditional boundaries of psychopathology and lead to more effective treatments and identification of new targets for prevention.