Integrated Toxicomics & Environmental Measurement Facility Core

综合环境健康科学中心（CIEHS）的目标是了解生命如何 风格因素与人类健康和疾病中暴露于环境毒物相互作用， 提高路易斯维尔大学（UofL）的环境健康研究能力。UofL 共享资源设施核心提供尖端的科学服务， 设备、先进技术和专门知识， 调查员现代环境健康科学家必须了解 现有的共享资源设施核心;在可访问性、有效的实验设计、数据- 采集和分析。综合毒理学和环境测量设施核心 （ITEMFC）将为CIEHS成员创建一个中央资源，使他们能够了解，访问和 有效利用环境经济资源。ITEMFC将协调CIEHS之间的活动 成员和现有的UofL共享资源设施核心。ITEMFC将由六个 离散的技术为中心的组成部分：基因组学/转录组学，蛋白质组学，代谢组学， 金属组学、宏基因组学和受控吸入暴露研究。ITEMFC将专注于 努力为研究者提供研究设计方面的建议，促进共享资源设施核心的使用， 教育中心成员和受训人员了解这些技术。此外，ITEMFC将促进 将组学数据转移到生物统计和信息学设施核心（BIFC）。它将实现 通过以下具体目标实现这些目标：目标1。增加获得和便利使用UofL 共享资源设施核心。ITEMFC将通过以下方式为我们的成员服务：（a）解释各种核心， 它们是如何运作的，（B）与正确的共享资源主管建立直接的互动， 合适的技术。我们将协助实验设计，并与所有机构密切合作， 简化样品处理和数据分析的核心。ITEMFC还将补充 成员研究。目标2.培养对ITEMFC的认识、兴趣和理解 资源设施核心。ITEMFC将通过以下方式支持CIEHS成员：（a）提请注意 共享资源设施核心，（B）建议ITEMFC如何加强其方法， 回答他们的研究问题，（c）支持教育下一代环境保护者， 科学家在各种技术。目标3。协助提交CIEHS成员赠款 建议使用ITEMFC资源的应用程序。ITEMFC将支持CIEHS成员开展 包括基于组学的目标的资助申请。ITEMFC的综合服务和专业知识 对于实现CIEHS的目标和在了解不同的 暴露于环境毒物以及生活方式因素的病理后果。

The Center for Integrated Environmental Health Sciences (CIEHS) goals are to understand how life style factors interact with exposure to environmental toxicants in human health and disease, and to enhance the capacity for environmental health research at the University of Louisville (UofL). UofL shared resource facility cores offer cutting edge scientific services, enabling access to high-end equipment, advanced techniques and specialized expertise that would typically be inaccessible for an investigator. It is essential for the modern environmental health scientist to understand the numerous available shared resource facility cores; in terms of accessibility, effective experimental design, data- acquisition and -analyses. The Integrated Toxicomics and Environmental Measurement Facility Core (ITEMFC) will create a central resource for CIEHS members, allowing them to understand, access and effectively use environmental ‘omics resources. The ITEMFC will coordinate activities between CIEHS members and the existing UofL shared resource facility cores. The ITEMFC will be comprised of six discrete technology-centric components: genomics/ transcriptomics, proteomics, metabolomics, metallomics, metagenomics, and controlled inhalation exposure studies. The ITEMFC will focus its efforts on advising investigators on study design, facilitating shared resource facility cores use, and educating Center members and trainees on these technologies. Additionally, the ITEMFC will facilitate the transfer of ‘omics data to the Biostatistics and Informatics Facility Core (BIFC). It will accomplish these goals through the following specific aims: Aim 1. Increase access and facilitate use of UofL shared resource facility cores. ITEMFC will serve our members by (a) explaining the various cores and how they operate, (b) establishing direct interactions with the right shared resource director to select the appropriate technology. We will aid in experimental design and closely collaborate with all Facility Cores to streamline sample handling and data analysis. The ITEMFC will also supplement the cost of member studies. Aim 2. Cultivate awareness, interest and understanding of the ITEMFC shared resource facility cores. The ITEMFC will support CIEHS members by (a) drawing attention to the shared resource facility cores, (b) suggesting how the ITEMFC may enhance their approach in answering their research questions, and (c) support educating the next generation of environmental scientists in the various technologies. Aim 3. Facilitate submission of CIEHS members’ grant applications proposing to use ITEMFC Resources. The ITEMFC will support CIEHS members in their grant applications that include ‘omics-based aims. The integrated services and expertise of the ITEMFC are essential to achieve CIEHS goals and to make progress with regard to understanding the diverse pathological consequences of exposure to environmental toxicants together with lifestyle factors.