Nuclear Control of Cell Growth and Differentiation Program (Project-001)

细胞生长和分化程序的核调控 摘要 核控制细胞生长和分化(NC)计划是一项基础科学计划，旨在 对癌细胞中出错的核过程提供重要的新理解。我们的会员资格 结合发现科学和临床前模型来剖析控制细胞生长和 差异化。我们成员(33名成员)的研究集中在三个科学主题上： 主题1-基因调控：基因网络、表观遗传学和RNA加工：这18个成员 研究肿瘤发生中重要的基因调控和染色质机制。 主题2-癌症代谢：基因网络和新陈代谢调控。这八名成员调查 癌症中代谢紊乱和转录/染色质扰动之间的相互作用。 主题3-基因组稳定性：DNA损伤和修复：这七个成员研究机制 在癌症中维持基因组的稳定性和它们的错误调控。 这一资助时期的主要成就包括对癌基因融合蛋白的新理解 肉瘤，发育和癌症中表观遗传调控的潜在机制，新基因和 基于代谢的癌症的潜在机制，对DNA修复机制的新见解，以及在 肉瘤、结肠癌和乳腺癌发现的基础到临床的翻译。 该计划由布拉德利·凯恩斯博士和贾里德·鲁特博士共同领导，33名成员来自 犹他大学设有11个系和3个学院，并指导了94名学员。积极的招聘导致了 自2009年以来有八名新成员。2013年，NC成员的研究经费总额为1310万美元，其中26% 来自NCI(2008年为7%)。绝大多数(89%)的正式成员拥有同行评审的资金，以及 许多人都获得了杰出的奖项。2013年，305种出版物(39%)报道了北卡罗来纳州的研究 与2009年相比有所增加)，其中19%是方案内协作，18%是方案间协作。 癌症中心通过提供最先进的设施、共享的 资源、方案资金和对招聘的支持。在接下来的五年里，NC程序将 继续推动有影响力的以癌症为重点的跨学科研究 协作性试点赠款，帮助组建协作性研究团队、赞助研讨会和专题讨论会 在关键感兴趣的领域，并利用我们的专业知识来开发基础设施和教育项目 对我们的会员和整个癌症中心都有好处。

NUCLEAR CONTROL OF CELL GROWTH AND DIFFERENTIATION PROGRAM ABSTRACT The Nuclear Control of Cell Growth and Differentiation (NC) Program is a basic science program that aims to provide important new understanding of the nuclear processes that go awry in cancer cells. Our membership combines discovery science and preclinical models to dissect nuclear mechanisms controlling cell growth and differentiation. The research of our membership (33 members) centers on three scientific themes: Theme 1—Gene Regulation: Gene Networks, Epigenetics, and RNA Processing: These 18 members investigate gene regulation and chromatin mechanisms of importance in oncogenesis. Theme 2—Cancer Metabolism: Gene Networks and Metabolic Regulation. These eight members investigate the interplay between metabolic derangements and transcriptional/chromatin perturbations in cancer. Theme 3—Genome Stability: DNA Damage and Repair: These seven members investigate the mechanisms that maintain genome stability and their misregulation in cancer. Major achievements in this funding period include a new understanding of oncogenic fusion proteins in sarcoma, mechanisms underlying epigenetic regulation in development and cancer, new genes and mechanisms underlying metabolism-based cancers, new insights into DNA repair mechanisms, and success in basic-to-clinical translation of discoveries in sarcoma, colon, and breast cancer. Co-Led by Bradley Cairns, PhD, and Jared Rutter, PhD, the Program's 33 members are drawn from 11 University of Utah departments in three colleges, and mentor 94 trainees. Active recruitment has led to eight new members since 2009. In 2013, NC members had $13.1M in total research funding, including 26% from NCI (up from 7% in 2008). The vast majority (89%) of full members have peer-reviewed funding, and many have received distinguished awards. In 2013, NC research was reported in 305 publications (a 39% increase from 2009) of which 19% were intra- and 18% were inter-programmatic collaborations. The Cancer Center enhances the Program's goals by providing state-of-the-art facilities, Shared Resources, programmatic funds, and support for recruitments. Over the next five years, the NC Program will continue to promote impactful transdisciplinary cancer-focused research through the strategic distribution of collaborative pilot grants, by helping to form collaborative research teams, sponsoring seminars and symposia in key areas of interest, and using our expertise to develop both infrastructure and educational programs of benefit to our membership and the entire Cancer Center.