Clinical Core

摘要 临床核心服务于USC ADRC的主题，脑血管和代谢对认知功能的贡献， 认知功能减退的血管和代谢危险因素;阿尔茨海默病的发病机制;以及预防 和治疗阿尔茨海默病相关疾病。核心的三个首要目标是：1）发展和 维持血管风险因素队列; 2）促进当地、临床和转化研究，包括早期阶段 临床试验; 3）为国家合作组织提供血管疾病，生物标志物和成像方面的专业知识 举措核心解决了2011年国家阿尔茨海默病项目法案（NAPA）的许多重要目标： 翻译工具，基础设施，试验设计和实施，新药靶点，对护理人员支持的研究， 招聘和公民参与，生物标志物，健康差距，数据共享和使能技术。 核心招募并保留主要ADRC队列，即，血管队列研究，脑研究 （尸检）研究，参与者共同入组附属研究。核心执行标准评估， 诊断，监督神经成像和血液和CSF生物标志物的收集。对于此次更新，核心计划 增加血管队列、尸检入组和Latinx参与;并继续提供 基础设施超过25个ADRC附属，独立资助的研究，包括南加州大学研究员- 启动了NIH资助的临床研究。核心是一个综合的协作团队，包括医生（Lon Schneider，Helena Chui，John Ringman，Elizabeth Joe，Sonia Pawluczyk），神经心理学家（Lina D 'Orazio， 卡罗尔·麦克利里）和其他调查人员（侯赛因·亚辛、朱迪·帕、迈克尔·哈灵顿）。 它的具体目标是：1）与其他ADRC核心合作，通过以下方式支持ADRC的中心主题 招募和维持血管风险队列; 2）招募和维持一个种族多样性队列， 对拉丁裔人，并强调血管和代谢风险，ADRC参与，和附属资助 3）招募和维持一个大脑研究队列，并与其他核心合作共享样本; 4)进行年度NACC统一数据集（UDS）评估，向NACC提交数据，促进综合 国家数据库，促进合作研究和数据共享; 5）推进南加州大学的参与， 领导国家合作研究，招聘，留住参与者在美国红十字会附属国家和 多中心项目; 6）加强招募和促进痴呆症预防工作和转化研究 与ORE核心合作的机会，特别是包括来自Latinx的参与者， 代表性不足的群体，以及南加州大学资助的阿尔茨海默病中心（CADC），以及 Roybal综合保健诊所;和7）支持神经成像和生物流体生物标志物研究。

Abstract The Clinical Core serves the USC ADRC’s themes, cerebrovascular and metabolic contributions to cognitive impairment; vascular and metabolic risk factors in cognitive decline; Alzheimer pathogenesis; and the prevention and treatment of Alzheimer-related disorders. The Core’s three overarching objectives are to: 1) develop and maintain a vascular risk factors cohort; 2) catalyze local, clinical and translational research, including early phase clinical trials; 3) provide expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The Core addresses many important goals of the 2011 National Alzheimer Project Act (NAPA): translational tools, infrastructure, trial design and conduct, novel drug targets, research on caregiver support, recruitment and citizen engagement, biomarkers, health disparities, data sharing, and enabling technologies. The Core enrolls and retains the primary ADRC cohorts, i.e., the Vascular Cohort Study, Brain Research (autopsy) Study, and participants co-enrolled in Affiliated-Studies. The core performs standard evaluations and diagnoses, oversees neuroimaging and blood and CSF biomarker collection. For this renewal, the core plans to increase the vascular cohort, enrollment for autopsy, and Latinx participation; and continue to provide infrastructure for over 25 ADRC-affiliated, independently-funded research studies including USC Investigator- initiated NIH-funded clinical studies. The core is an integrated, collaborative team, including physicians (Lon Schneider, Helena Chui, John Ringman, Elizabeth Joe, Sonia Pawluczyk), neuropsychologists (Lina D’Orazio, Carol McCleary), and other investigators (Hussein Yassine, Judy Pa, Michael Harrington). Its specific aims are to: 1) collaborate with the other ADRC cores to support the ADRC’s central theme by recruiting and maintaining the vascular risk cohort; 2) recruit and maintain an ethnically diverse cohort focusing on Latinx individuals and emphasizing vascular and metabolic risk, ADRC participation, and affiliated funded studies; 3) recruit and maintain a the Brain Research Study cohort and work with other cores to share specimens; 4) perform annual NACC Uniform Data Set (UDS) evaluations, submit data to NACC, promote an integrated national database, facilitate collaborative research and data sharing; 5) advance USC’s participation and leadership in national collaborative studies by recruiting, retaining participants in ADRC-affiliated national and multicenter projects; 6) enhance recruitment and promote dementia prevention efforts and translational research opportunities in collaboration with the ORE core that particularly includes participants from Latinx and underrepresented groups, and from the USC California-funded Alzheimer’s Disease Centers (CADC), and Roybal Comprehensive Healthcare Clinic; and 7) support neuroimaging and biofluid biomarker studies.