Pathology of the Alzheimer disease : prevention of cerebral β-amyloid deposition

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The purpose of the study is to find polyphenol, which reduce cerebral β-amyloid deposition, a causative factor of the Alzheimer disease. We administrated tannic acid to transgenic mice which develop cerebral β-amyloid deposition, and examined neuropathologically and behavior-physiologically. We found that tannic acid reduce cerebral β-amyloid deposition and also reduce mental deficit. Moreover, we demonstrated new findings as follows : accumulation of protofibril at synaptic area ; influence of ganglioside on amyloid angiopathy ; and β-amyloid deposition in tamarin.