Bio-medical and socio-economic precursors of cognitive decline in SHARE

项目摘要 这个项目的总体目标是利用国际上健康和生活环境的变化。 欧洲大陆确定生命过程中生物医学和社会经济状况的哪些相互作用 课程影响晚年生活的认知。该项目将利用欧盟资助的健康、老龄化和健康调查 欧洲退休(共享)，并阐述了NIA的一些关键研究优先事项：老年人研究 不同国家的成年人将提供有关认知状况的有价值的信息，并将其与 老年人的社会经济和社会环境以及可用作工具的生物标志物 有针对性地采取早期预防措施。它将增强我们对巨大差异的社会、健康和 长期护理系统影响老龄人口的心理健康和由此导致的死亡率。这一点成立 尤其是二战以来欧洲的生活环境，很可能影响了人们的认知能力 现在年龄较大的人会有所下降。此外，退休年龄等关键政策变量的巨大差异表明 从提前退休到不活动和失去社交关系到认知能力低下的途径，由 教育、工作环境和其他社会经济因素影响了人的一生。 SHARE是一个大型的具有人口代表性的小组研究，密切模仿美国的健康和退休 目前在27个欧洲大陆国家和以色列学习(HRS)。严格协调健康变量 对于大约80,000名受访者来说，包括自我报告的健康、功能健康、体格测量等 比如握力、峰值流量和座椅站立，以及大量的认知和心理健康测试。 此外，Share还从大约27,000名受访者中收集了干血迹样本。 该项目将填补人力资源报告和分享之间协调方面的两个战略空白。会的 1.根据协调认知评估对认知进行深入测量 为NIA支持的HRS类型的老龄化调查开发的协议(HCAP)。 2.分析Share收集的血液中是否有血脂和其他生物标志物 与认知功能减退、血管性痴呆和阿尔茨海默氏症相关。 利用这些数据，该项目将估计老年人轻度和严重认知障碍的患病率 分享国家；将这些与HRS和HCAP研究的其他参与者进行比较；并利用 股份加股份-HCAP数据的国际差异，以确定哪些交互作用 生命过程中的生物医学和社会经济状况会影响以后的认知。 这个项目与股票小组的长期议程是同步的，该小组在浪潮中收集了血液 6，目前正在管理第7波中的生活史模块，并将在 第8波。资金仅限于为Share-HCap收集额外数据的努力和对 在第6波和SHARE-HCAP子研究中采集血液，寻找与认知能力下降相关的标记物。

PROJECT ABSTRACT The general aim of this project is to exploit the international variation of health and life circumstances in Continental Europe to identify which interactions of bio-medical and socio-economic conditions over the life course affect cognition in later life. The project will leverage the EU-funding of the Survey of Health, Aging and Retirement in Europe (SHARE) and addresses a number of key research priorities for NIA: The study of older adults in a diverse array of countries will provide valuable information on cognitive status and relate it to the socio-economic and social environment of the elderly as well as biomarkers that may serve as instruments to target early prevention measures. It will enhance our understanding how the vastly differing social, health and long-term care systems affect mental health and resulting mortality of the aging populations. This holds especially for the life circumstances in Europe since World War II which are likely to have influenced cognitive decline now at older ages. Moreover, the large variation in key policy variables, e.g. retirement age, identifies pathways from early retirement through inactivity and loss of social contacts to lower cognition, mediated by education, working environment and other socio-economic factors over the life-course. SHARE is a large population-representative panel study closely modeled after the US Health and Retirement Study (HRS) in currently 27 Continental European countries plus Israel. Strictly harmonized health variables for the about 80,000 respondents include self-reported health, functional health, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. Moreover, SHARE has collected dried blood spot samples from some 27,000 respondents. The project will fill two strategic gaps in the harmonization between HRS and SHARE. It will 1. Administer an in-depth measurement of cognition according to the Harmonized Cognitive Assessment Protocol (HCAP) that has been developed for the HRS-style aging surveys supported by NIA. 2. Analyze the blood collected by SHARE for blood lipids and other biomarkers that have been found to correlate with cognitive decline, vascular dementia and Alzheimer's disease. Using these data, the project will estimate prevalence rates of mild and severe cognitive impairment in the SHARE countries; compare these with HRS and other participants in the HCAP studies; and exploit the international variation of the SHARE plus SHARE-HCAP data in order to identify which interactions of biomedical and socioeconomic conditions over the life course affect cognition later in life. This project is synchronized with the long-run agenda of the SHARE panel which has collected blood in wave 6, is currently administering a life-history module in Wave 7 and will feature an extended cognition module in Wave 8. Funding is restricted to the additional data collection efforts for SHARE-HCAP and the analyses of blood taken in wave 6 and in the SHARE-HCAP substudy for markers associated with cognitive decline.