Asthma and Allergic Diseases Group

项目概要/摘要-哮喘和过敏性疾病组 通过这一资助机会公告，NIAID过敏，免疫学和 移植（DAIT）打算巩固其多个，独立的统计和临床 协调中心（SACCs）合并为一个单一的多组成部分合作协议， 成本，提高效率和标准化的研究联盟。这一新项目将为A 单一SACC或中心支持DAIT在哮喘和过敏性疾病、自身免疫性疾病 在哮喘和过敏性疾病研究领域，该中心将 支持5个联盟-哮喘和过敏性疾病合作研究中心（AADCRC）， 特应性皮炎研究网络（ADRN），食物过敏研究联盟（CoFAR）， Inner-City Asthma Consortium（ICAC）和免疫耐受网络的哮喘和过敏部分 （ITN）。在该中心内，对这5个联盟的支持将分为一个小组-哮喘和 过敏疾病组（AADG）。AADG的目标是提供优秀和有效的研究 在5个哮喘和过敏性疾病研究联盟之间提供协调支持服务。完成 为此，RhoFED旨在（1）提供在哮喘和过敏性疾病研究方面经验丰富的工作人员 由DAIT支持的财团进行，并将这些工作人员组织在一个管理结构中， 有效地利用资源，响应研究联盟和DAIT的需求，并促进 （2）提供经验丰富的科学家和统计学家，他们与 临床研究人员和DAIT高级官员，设计和分析整个研究范围的研究， 哮喘和过敏性疾病;（3）促进初始和后续的发展，审查和修订 通过专门的AADG协议团队起草协议和协议相关文件;以及（4）提供 研究启动和研究管理职能，这些职能是有效、有效和合乎伦理地开展研究所必需的 问题研究此外，行政助理总干事还将支持继续维持ADRN主题登记册和廉政公署 临床标本库。由于RhoFED目前是ADRN、ICAC和ITN的SACC， 维护ADRN受试者登记处和ICAC临床标本库，RhoFED非常适合 为5个联盟提供统一的SACC支持。而且，通过为工作人员提供以下方面的经验， 支持哮喘和过敏性疾病研究联盟和行政基础设施， 加强各方之间的协作，支持灵活有效的资源管理，我们相信， 通过新成立的中心和AADG对这5个联盟的支持将直接有助于 实现DAIT目标，以更好地了解、治疗和预防哮喘和过敏性疾病。

PROJECT SUMMARY/ABSTRACT—ASTHMA AND ALLERGIC DISEASES GROUP Through this Funding Opportunity Announcement, the NIAID Division of Allergy, Immunology and Transplantation (DAIT) intends to consolidate its funding for multiple, independent Statistical and Clinical Coordinating Centers (SACCCs) into a single multi-component cooperative agreement, presumably to reduce costs and increase efficiency and standardization across research consortia. This new program will fund a single SACCC or Center to support DAIT research in the areas of asthma and allergic diseases, autoimmune diseases, and transplantation, and in the area of asthma and allergic diseases research, this Center will provide support to 5 consortia—the Asthma and Allergic Diseases Cooperative Research Centers (AADCRCs), the Atopic Dermatitis Research Network (ADRN), the Consortium of Food Allergy Research (CoFAR), the Inner-City Asthma Consortium (ICAC), and the asthma and allergy component of Immune Tolerance Network (ITN). Within the Center, support for these 5 consortia will be organized under 1 group—the Asthma and Allergy Diseases Group (AADG). The objective of the AADG is to provide excellent and efficient study coordination support services across the 5 asthma and allergic diseases research consortia. To accomplish this objective, RhoFED aims to (1) provide staff experienced in asthma and allergic disease research conducted by DAIT-supported consortia and to organize these staff in an administrative structure that manages resources efficiently, is responsive to the needs of the research consortia and DAIT, and facilitates communication and collaboration; (2) provide experienced scientists and statisticians who, in collaboration with clinical investigators and senior DAIT officials, design and analyze studies across the full scope of research in asthma and allergic diseases; (3) facilitate the development, review, and revision of initial and successive drafts of protocols and protocol-related documents through dedicated AADG protocol teams; and (4) provide study initiation and study management functions that are required for the efficient, valid, and ethical conduct of studies. In addition, the AADG will support the continuation of the ADRN Subject Registry and the ICAC Clinical Specimen Repository. Because RhoFED is currently the SACCC for ADRN, ICAC, and ITN and maintains the ADRN Subject Registry and the ICAC Clinical Specimen Repository, RhoFED is well suited to provide consolidated SACCC support across the 5 consortia. And, by providing staff with experience in supporting asthma and allergic disease research consortia and an administrative infrastructure designed to enhance collaboration between parties and support agile and effective resource management, we believe that support of these 5 consortia through the newly formed Center and the AADG will directly contribute to the achievement of the DAIT objective to better understand, treat, and prevent asthma and allergic diseases.