UAB Diabetes Research Center

这项提议将继续推进2008年首次成立的UAB刚果民主共和国的进程。我们的使命是：“缓解 糖尿病和心脏代谢性疾病带来的痛苦和社会负担， 多学科、基础和转化性研究和研究培训，这有助于加深对 疾病机制、预防和治疗“。9年来，DRC推动了UAB的研究 围绕糖尿病研究的社区，成员人数增加了69%，从115人增加到194人，并 积极的校外糖尿病研究经费增加到每年62,427,510美元的直接费用。我们的 中心的目标是促进糖尿病研究的卓越，进一步培养有凝聚力的知识分子 社区促进协作和创新，并提供良好的培训和 职业发展。我们的研究强调糖尿病既是一种代谢性疾病也是一种血管疾病。 包括分子信号、胰岛生物学和自身免疫等研究领域， 综合代谢血管疾病/炎症，糖尿病并发症，遗传学和流行病学，以及 干预和基于社区的研究。我们的具体目标是： 1.通过资助我们明确要求的研究核心设施，促进和加强糖尿病研究 研究人员基础，涵盖广泛的翻译范围：生物分析氧化还原生物学，动物 生理学、人类生理学和干预与翻译核心。 2.通过一项强调创新的试点和可行性拨款计划，加强糖尿病研究。 翻译，以及非常有前途的初级调查人员的职业发展。 3.发起一项综合充实计划，为杰出的 多学科研究人员基地，将加强学习、合作、合作和创新。 4.强调研究、培训和推广，以满足学员的需求，实现 为我们的患者提供更好的结果，并减轻我们社区和国家的糖尿病沉重负担。 5.响应我们调查人员不断变化的需求，并通过推动新想法和 调查路线，并利用UAB领导层的决心、实质性的机构承诺以及 我们的社会慷慨的慈善事业进一步推动了一个卓越的 糖尿病研究在南方腹地的卓越地位。 DRC对UAB在糖尿病研究方面的卓越表现产生了显著影响 是美国糖尿病患病率最高的国家，并已联合研究人员围绕共同主题研究糖尿病 在心脏代谢疾病的背景下。我们有信心实现进一步的发展和发展 在接下来的5年里。

This proposal will continue progress of the UAB DRC first established in 2008. Our mission is: “Alleviate suffering and the social burden caused by diabetes and cardiometabolic disease through innovative, multidisciplinary, basic and translational research and research training, which advances understanding of disease mechanisms, prevention, and treatment”. Over 9 years, the DRC has galvanized the UAB research community around the study of diabetes resulting in increased membership by 69% from 115 to 194 and an increase in active extramural diabetes research funding to a total of $62,427,510 annual direct costs. Our center’s goals are to facilitate excellence in diabetes research, further develop a cohesive intellectual community promoting collaboration and innovation, and provide an outstanding environment for training and career development. Our research emphasizes the study of diabetes as both a metabolic and vascular disease and includes areas of research excellence including molecular signaling, islet biology & autoimmunity, integrative metabolism vascular disease/inflammation, diabetes complications, genetics & epidemiology, and interventions & community based research. Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base and that cover a broad translational spectrum: Bioanalytical REDOX Biology, Animal Physiology, Human Physiology, and Interventions & Translation Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Emphasize research, training, and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 5. Respond to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation, and leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. The DRC has exerted a pronounced impact on diabetes research excellence at UAB in a community with the highest rates of diabetes in the US, and has united investigators around common themes to study diabetes in the context of cardiometabolic disease. We are confident that further evolution and growth will be achieved over the next 5 years.