Acceptance-Based Therapy Weight Loss Intervention for Adolescents: A Pilot, Randomized Controlled Trial

项目摘要/摘要 培训：我对肥胖的研究主要集中在儿童肥胖的病因上，以及自然肥胖 我学术生涯的下一步是设计、开发和实施基于证据的减肥方法 超重/肥胖青少年的干预(OW/OB)。拟议的K01职业发展培训 Plans以我以前的经验为基础，将重点放在需要额外培训的三个领域：(1)在 设计和实施青少年肥胖减肥试验，(2)培养行为方面的专业知识 改变理论，包括基于接受的治疗(ABT)，以及(3)提高实施科学的技能。 因此，我们建议加强专题指导、集中课程、实践、研讨会和 通过拟议的研究进行情景学习。此K01将提供受保护的时间以接收 必要的培训，以增强我在这三个领域的专业知识，并将推动我成为一名 独立研究科学家专注于制定有效的青少年肥胖干预措施。 研究：美国青少年OW/OB患病率为34.5%目前可用的有效性 青少年减肥干预是有限的，因为减重量适中，体重回升 是很常见的。因此，迫切需要对患有OW/OB的青少年进行有效的干预。这个 建议的K01试图满足这一需求，而这项K01建议的目标是开发和测试 为OW/OB青少年量身定做的ABT减肥干预的可行性、可接受性和有效性。 ABT注重自我调节技能和增加对负面或不舒服情绪的容忍度，以及 研究表明，这对成年人来说是一种非常有效的减肥策略。此外，ABT已经被 成功地治疗了患有慢性疼痛、高危性行为、厌食症和抑郁症的青少年。 鉴于ABT在治疗青少年其他医学和行为问题方面的成功，以及 在成年人观察到的体重下降中，ABT可能代表着一种有效的青少年减肥干预措施。 然而，到目前为止，还没有人将ABT作为青少年减肥工具进行研究。因此，拟议的K01将 为患有OW/OB的青少年制定ABT干预措施。这项提议的首要假设是 青少年ABT干预将是可行的、可接受的，并将导致较低的BMI z得分和 体脂百分比，更健康的饮食摄入量，增加体力活动，改善血压和 与增强的标准护理条件相关的胆固醇。摘要：这项研究的结果将为 R01拨款申请，以测试青少年ABT减肥干预的有效性 样本。这款K01将发展我在青少年肥胖症试验中的新专业知识，应用行为 将理论转变为干预发展和实施科学。在这个奖项结束时，我将成为一名 领先的独立科学家在青年中进行有效的减肥干预。

PROJECT SUMMARY/ABSTRACT Training: My research on obesity has focused primarily on the etiology of pediatric obesity, and the natural next step in my academic career is to design, develop, and implement an evidence-based weight loss intervention for adolescents with overweight/obesity (OW/OB). The proposed K01 career development training plan builds upon my prior experience to focus on three areas that require additional training: (1) build skills in designing and implementing obesity weight loss trials in adolescents, (2) develop expertise in behavioral change theories, including acceptance based-therapy (ABT), and (3) enhance skills in implementation science. Accordingly, we propose intensive topical mentorship, focused coursework, practicums, seminars, and contextual learning through the proposed research. This K01 will provide protected time to receive the necessary training to enhance my expertise in these three areas and will propel me to becoming an independent research scientist focused on the development of effective obesity interventions in youth. Research: The prevalence of OW/OB in U.S. adolescents is 34.5%. The effectiveness of currently available adolescent weight loss interventions is limited because the amount of weight lost is modest and weight regain is common. Thus, there is a critical need to develop effective interventions in adolescents with OW/OB. The proposed K01 attempts to address this need and the objective of this K01 proposal is to develop and test the feasibility, acceptability, and efficacy of an ABT weight loss intervention tailored for adolescents with OW/OB. ABT focuses on self-regulation skills and increasing tolerance of negative or uncomfortable emotions, and research demonstrates that it is a highly effective weight loss strategy in adults. Further, ABT has been successful in treating adolescents with chronic pain, high-risk sexual behavior, anorexia, and depression. Given the success of ABT for treating other medical and behavioral issues in adolescents and the high percent of weight loss observed in adults, ABT could represent an effective weight loss intervention for adolescents. However, to date, no one has studied ABT as an adolescent weight loss tool. Thus, the proposed K01 will develop an ABT intervention tailored for adolescents with OW/OB. The overarching hypothesis of this proposal is that an adolescent ABT intervention will be feasible, acceptable, and will result in lower BMI z-scores and body fat percentage, healthier dietary intakes, increased physical activity, and improved blood pressure and cholesterol relative to an enhanced standard care condition. Summary: Findings from this study will inform an R01 grant application to test the effectiveness of an adolescent ABT weight loss intervention in a fully-powered sample. This K01 will develop my new expertise in conducting adolescent obesity trials, applying behavioral change theories to intervention development, and implementation science. At the end of this award, I will be a leading independent scientist conducting effective weight loss interventions in youth.