Acceptance-Based Therapy Weight Loss Intervention for Adolescents: A Pilot, Randomized Controlled Trial

青少年基于接受的治疗减肥干预：一项随机对照试验

• 批准号: 9503231
• 负责人: Michelle Cardel
• 金额: $ 14.92万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9503231
• 关键词: 19 year old; Address; Adolescent; Adolescent obesity; Adult; Affect; Aftercare; Anorexia; Applications Grants; Area; Award; Behavior Therapy; Behavioral; Biological; Blood Pressure; Body Composition; Body Weight; Body Weight decreased; Body fat; Body mass index; Caring; Cholesterol; Communities; Cues; Development; Devices; Diet; Dietary intake; Doctor of Philosophy; Educational Background; Educational Curriculum; Effectiveness; Emotions; Energy Intake; Etiology; Feedback; Florida; Focus Groups; Fostering; Goals; Hyperphagia; Informal Social Control; Intervention; Interview; K-Series Research Career Programs; Learning; Manuals; Medical; Mental Depression; Mentors; Mentorship; Modification; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Participant; Physical activity; Population; Prevalence; Process; Race; Randomized; Randomized Controlled Trials; Research; Research Personnel; Sampling; Savings; Scientist; Testing; Theory of Change; Therapeutic Intervention; Time; Training; Training Activity; Weight; Youth; base; cardiovascular disorder risk; career; career development; chronic pain; craving; demographics; design; effective intervention; evidence base; experience; follow-up; health organization; high risk sexual behavior; implementation science; improved; innovation; intervention participants; novel; obesity in children; pediatrician; pilot trial; racial and ethnic; racial diversity; recruit; satisfaction; sedentary lifestyle; sex; skills; standard care; success; therapy development; tool; trial comparing; weight loss intervention; weight loss program

PROJECT SUMMARY/ABSTRACT Training: My research on obesity has focused primarily on the etiology of pediatric obesity, and the natural next step in my academic career is to design, develop, and implement an evidence-based weight loss intervention for adolescents with overweight/obesity (OW/OB). The proposed K01 career development training plan builds upon my prior experience to focus on three areas that require additional training: (1) build skills in designing and implementing obesity weight loss trials in adolescents, (2) develop expertise in behavioral change theories, including acceptance based-therapy (ABT), and (3) enhance skills in implementation science. Accordingly, we propose intensive topical mentorship, focused coursework, practicums, seminars, and contextual learning through the proposed research. This K01 will provide protected time to receive the necessary training to enhance my expertise in these three areas and will propel me to becoming an independent research scientist focused on the development of effective obesity interventions in youth. Research: The prevalence of OW/OB in U.S. adolescents is 34.5%. The effectiveness of currently available adolescent weight loss interventions is limited because the amount of weight lost is modest and weight regain is common. Thus, there is a critical need to develop effective interventions in adolescents with OW/OB. The proposed K01 attempts to address this need and the objective of this K01 proposal is to develop and test the feasibility, acceptability, and efficacy of an ABT weight loss intervention tailored for adolescents with OW/OB. ABT focuses on self-regulation skills and increasing tolerance of negative or uncomfortable emotions, and research demonstrates that it is a highly effective weight loss strategy in adults. Further, ABT has been successful in treating adolescents with chronic pain, high-risk sexual behavior, anorexia, and depression. Given the success of ABT for treating other medical and behavioral issues in adolescents and the high percent of weight loss observed in adults, ABT could represent an effective weight loss intervention for adolescents. However, to date, no one has studied ABT as an adolescent weight loss tool. Thus, the proposed K01 will develop an ABT intervention tailored for adolescents with OW/OB. The overarching hypothesis of this proposal is that an adolescent ABT intervention will be feasible, acceptable, and will result in lower BMI z-scores and body fat percentage, healthier dietary intakes, increased physical activity, and improved blood pressure and cholesterol relative to an enhanced standard care condition. Summary: Findings from this study will inform an R01 grant application to test the effectiveness of an adolescent ABT weight loss intervention in a fully-powered sample. This K01 will develop my new expertise in conducting adolescent obesity trials, applying behavioral change theories to intervention development, and implementation science. At the end of this award, I will be a leading independent scientist conducting effective weight loss interventions in youth.

项目摘要/摘要 培训：我对肥胖症的研究主要集中在儿科肥胖的病因上，自然 我的学术生涯的下一步是设计，开发和实施基于证据的减肥 对超重/肥胖的青少年进行干预（OW/OB）。拟议的K01职业发展培训 计划以我先前的经验为基础，专注于需要额外培训的三个领域：（1）建立技能 在青少年设计和实施肥胖症减肥试验，（2）发展行为方面的专业知识 改变理论，包括基于接受的治疗（ABT）和（3）增强实施科学技能。 因此，我们提出了密集的主题指导，专注的课程，实践，研讨会和 通过拟议的研究进行上下文学习。该K01将提供受保护的时间接收 必要的培训以增强我在这三个领域的专业知识，并将推动我成为一个 独立的研究科学家致力于发展青年有效的肥胖干预措施。 研究：美国青少年的OW/OB的患病率为34.5％。当前可用的有效性 青少年减肥干预措施受到限制 很常见。因此，在OW/OB的青少年中制定有效的干预措施迫切需要。这 拟议的K01试图解决这一需求，该K01提案的目的是开发和测试 为OW/OB的青少年量身定制的ABT减肥干预措施的可行性，可接受性和功效。 ABT专注于自我调节技能，增加对负面或不舒服的情绪的容忍度，以及 研究表明，这是成人的高效减肥策略。此外，ABT一直 成功地治疗慢性疼痛，高风险性行为，厌食和抑郁症的青少年。 鉴于ABT成功治疗青少年的其他医学和行为问题 在成年人中观察到的体重减轻，ABT可以代表青少年的有效减肥干预措施。 但是，迄今为止，还没有人研究ABT作为青少年减肥工具。因此，拟议的K01将 开发针对具有OW/OB的青少年量身定制的ABT干预措施。该提议的总体假设 是青少年的ABT干预将是可行的，可接受的，并且会导致BMI Z分数较低，并且 体内脂肪百分比，更健康的饮食摄入量，增加体育锻炼，血压提高 胆固醇相对于增强的标准护理条件。摘要：这项研究的发现将告知 R01赠款应用以测试青少年减肥干预措施的有效性 样本。该K01将在进行青少年肥胖试验方面发展我的新专业知识，应用行为 将理论改为干预发展和实施科学。在这个奖项结束时，我将成为 领先的独立科学家对青年进行有效的减肥干预措施。