Core I: 90+ Cohort

酷睿I：90+酷睿 项目摘要/摘要 90+核心的总体目标是扩大90+研究(R01AG20055，MPI：C)的整合。 科拉达)的数据和资源进入UCI ADRC的研究环境。90岁以上的研究是一项 正在对UCI最年长的老人进行纵向研究，该老人已经运营了16年，并获得了 来自具有良好特征的参与者的无与伦比的高质量数据，包括临床、影像、 遗传和神经病理数据。这项研究已经成为研究最古老的- 老年人，90岁及以上的人。年龄最大的人代表着人口中增长最快的部分 并有最高的痴呆症发病率。然而，年龄最大的个体被严重低估，因为他们经常 被排除在研究之外。90+核心包括来自90+研究的参与者，他们同意使用Brain 尸检或脑部成像。90+酷睿将作为集中化资源，以提高以下各项的容量： 需要进行最古老的研究，并将能够有效地管理和协调资源和 UCI ADRC内外90多项研究和ADRD研究环境之间的合作。 数据和资源的高效共享和分发将鼓励对最古老的 最终目标是了解痴呆症及其病理基础、认知障碍、弹性、 以及生物标志物在我们最年长的公民中的作用。 90+Core将协调同意的参与者的脑捐赠和尸检脑核磁共振 尸检，将增加从代表性不足的种族中招募个人参加我们的尸检和 影像研究，并将确定与其他ADRC调查人员相关的参与者。此外，90+酷睿 还将组装和维护易于访问、未识别、相互链接的数据资源，其中包括 临床、生物标记物、遗传学和神经病理学数据，以促进资源共享并将制定策略 用于处理与最古老的研究特别相关的分析问题。最后，特别是 对年龄最大的老人进行研究的专业知识，90+Core将有助于教育和培训 下一代ADRD临床医生和研究人员。 在与其他核心和研究教育组成部分的密切合作下，90+核心将提供 联系和协作的机会，并将作为促进和鼓励的集中资源 在UCI ADRC和更大的AD生态系统中进行的最古老的新颖研究。

Core I: The 90+ Core Project Summary/Abstract The overall objective of the 90+ Core is to expand the integration of The 90+ Study's (R01AG20055, MPI: C. Kawas, M. Corrada) data and resources into the research environment of the UCI ADRC. The 90+ Study is an ongoing longitudinal study of the oldest-old at UCI that has been operating for 16 years and has acquired an unparalleled amount of high-quality data from well-characterized participants including clinical, imaging, genetic, and neuropathological data. The study has become an invaluable resource for research on the oldest- old, people 90 years of age and older. The oldest-old represent the fastest growing segment of the population and have the highest rates of dementia. Yet, oldest-old individuals are severely understudied as they are often excluded from research. The 90+ Core includes participants from The 90+ Study who have agreed to brain autopsy or brain imaging. The 90+ Core will act as a centralized resource to improve the capacity for much- needed research in the oldest-old and will enable effective management and coordination of resources and collaboration between The 90+ Study and the ADRD research environment within and beyond the UCI ADRC. The efficient sharing and distribution of data and resources will encourage research in the oldest-old with the ultimate goal of understanding dementia and its pathological underpinnings, cognitive impairment, resilience, and the role of biomarkers in our oldest citizens. The 90+ Core will coordinate brain donation and post-mortem brain MRI from participants who have agreed to autopsy, will increase recruitment of individuals from underrepresented ethnicities into our autopsy and imaging studies, and will identify participants relevant to other ADRC investigators. In addition, The 90+ Core will also assemble and maintain an easily accessible, de-identified, interlinked data resource that includes clinical, biomarker, genetics, and neuropathology data to facilitate resource sharing and will develop strategies for handling analytic problems particularly relevant to research in the oldest-old. Finally, with particular expertise for conducting studies of the oldest-old, The 90+ Core will contribute to the education and training of the next generation of ADRD clinicians and researchers. In close collaboration with other Cores and the Research Education Component, The 90+ Core will provide opportunities to connect and collaborate and will serve as a centralized resource to facilitate and encourage novel research in the oldest-old across the UCI ADRC and larger AD ecosystem.