Pilot Project Program

试点项目方案的项目摘要 我们试点项目计划(PPP)的目标是为研究提供资金(每个奖项高达3.5万美元)，获得 最先进的设施核心(FCS)和智力支持，主要面向初级教职员工和招聘高级教职员工 曼哈顿北部环境健康中心(CEHNM)的教师。资金是针对项目的 这促进了我们对生命过程中环境暴露对健康影响的理解，通过 重点关注本供资周期的四个主题：环境流行病学、环境表观遗传学和 疾病机制、气候与健康、翻译与疾病预防。除了支持 当前CEHNM主题，购买力平价被用来鼓励国外新方向的研究发展 将这些主题作为开发新的重点领域的一种方式。PPP还寻求为关注的项目提供资金 当地社区(如西哈莱姆区、中央哈莱姆区、华盛顿高地/因伍德和南布朗克斯)， 由我们的社区参与核心(CEC)确定。购买力平价成功地激发了人们对 非中心成员的大学初级和高级调查人员的环境健康问题 并为他们提供了我们在CEHNM的高级调查人员的专业知识以及我们的 尚未完成的FCS，使它们能够为新的赠款申请生成初步数据。的成功之处 PPP是通过授予试点项目(PP)调查人员的新的外部拨款来衡量的，出版物 PP研究的结果，初级教员的支持，CEHNM社区的新调查人员，以及新的 开发了跨学科项目。通过所有这些措施，购买力平价取得了非凡的成功。 2008-2014年间(最后一个周期和本周期的头两年)，公私伙伴关系收到76份提案，其中28份 都得到了资助。在这些PPS上投资的71.3万美元产生了6个R01、2个R21、2个K奖、1个R33和13个其他奖项 总计2,010万美元的新赠款(试点项目每资助1美元，赠款为28美元)，以及32个PP 出版物。所有资助的PPS都流向了初级教职员工或调查人员，他们还没有 CEHNM调查人员。对于拟议的供资周期，试点项目方案的具体目标如下 目标1.培育填补重大研究空白的创新环境健康科学研究 在CEHNM工作组领域确定，并为今后CEHNM研究的发展做准备 方向。目标2.支持初级教员开发创造性的、新颖的研究项目，以促进 建立一个独立的研究项目，促进他们的事业发展。目标3.引进新的教员 从大学到CEHNM社区的成员进行创新研究，填补关键的空白 环境健康科学研究。目标4.促进回答重大环境问题的研究 CEC提出的健康问题。总而言之，我们的购买力平价具有支持 开发重大、创新的环境健康研究和培训调查人员，他们不仅 未来将进行更多此类研究，但也将成为该领域的领先者。

Project Summary of the Pilot Projects Program The goal of our Pilot Project Program (PPP) is to provide funding for research (up to $35k per award), access to state-of-the-art Facility Cores (FCs), and intellectual support primarily for junior faculty and to recruit senior faculty to the Center for Environmental Health in Northern Manhattan (CEHNM). Funding is targeted to projects that advance our understanding of the health impacts of environmental exposures over the life course, with a focus on the four themes for this funding cycle: Environmental Epidemiology, Environmental Epigenetics and Disease Mechanisms, Climate and Health, and Translation and Disease Prevention. In addition to supporting current CEHNM themes, the PPP is used to encourage the development of research in new directions outside of those themes as a way to develop novel areas of focus. The PPP also seeks to fund projects that concern the local communities (e.g., West Harlem, Central Harlem, Washington Heights/Inwood and the South Bronx), as identified by our Community Engagement Core (CEC). The PPP has successfully stimulated interest in environmental health issues by junior and senior investigators at the University who are not Center Members and provided them with access to the expertise of our senior investigators in the CEHNM as well as to our outstanding FCs, which enabled them to generate preliminary data for new grant applications. The success of the PPP is measured by new extramural grants awarded to Pilot Project (PP) investigators, publications resulting from PP research, junior faculty supported, new investigators to the CEHNM community, and new interdisciplinary projects developed. By all of these measures, the PPP has been an extraordinary success. Between 2008-2014 (last cycle and first two years of this cycle), the PPP received 76 proposals, of which 28 were funded. The $713K invested in these PPs resulted in 6 R01s, 2 R21s, 2 K awards, 1 R33, and 13 other grants for a total of $20.1M in new grants ($28 in grants for every $1 funded in pilots), as well as 32 PP publications. All of the funded PPs went to either junior faculty members or investigators who were not already CEHNM investigators. For the proposed funding cycle, the Specific Aims of the Pilot Project Program are as follows: Aim 1. Foster innovative environmental health science research that fills important research gaps identified in CEHNM working group areas and allows for the development of future CEHNM research directions. Aim 2. Support junior faculty members in developing creative, novel research projects that facilitate the establishment of an independent research program and further their careers. Aim 3. Bring new faculty members from the University to the CEHNM community to conduct innovative research that fills critical gaps in environmental health science research. Aim 4. Facilitate research that answers significant environmental health questions raised by the CEC. In summary, our PPP has a demonstrated history of supporting the development of significant, innovative environmental health research and training investigators who not only will conduct more of such research in the future but also become leaders in the field.