Pet Exposure, Allergy and Early Asthma in the Inner-City

内城区的宠物接触、过敏和早期哮喘

• 批准号: 6932046
• 负责人: MATTHEW S PERZANOWSKI
• 金额: $ 8.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932046
• 关键词: African American; Hispanic Americans; Mus musculus; allergens; antibody; asthma; cats; clinical research; cockroach; disease /disorder proneness /risk; dogs; domestic animals; dust; environmental exposure; human pregnant subject; immune response; immunoglobulin E; immunoglobulin G; longitudinal human study; questionnaires; respiratory disorder epidemiology; urban area

DESCRIPTION (provided by applicant): Recent evidence has shown that early life exposure to cats and dogs in the home may protect against allergic sensitization and asthma in certain communities. This pet protective effect, however, has not been extensively studied either in the inner city or in a setting where children are exposed to high levels of cockroach and mouse allergen. An ongoing birth cohort study currently being conducted in northern Manhattan by the Columbia Center for Children's Environmental Health offers an ideal opportunity to study this phenomenon in an inner-city community. We hypothesize that for children living in the inner city exposed to cockroach and mouse allergens, exposure to high concentrations of cat and dog allergens early in life decreases the risk of developing pet-specific IgE responses and allergic symptoms. This hypothesis is based on a protective effect of pet ownership observed elsewhere, and a discrepancy in the reported general atopy protective effect reported in communities without the major allergen, dust mite (e.g., Sweden), but not observed in communities with a significant mite population (e.g., New Zealand). The specific aims are designed to elucidate the role of high dose cat and dog allergen exposure in the development of allergic disease in inner-city children, commonly exposed to cockroach and mouse allergens: 1) Determine the level of pet allergen in the home over multiple time-points and validate the data with questionnaire data. This will allow us to better quantify cumulative pet allergen exposure. 2) Determine the early life allergen specific antibody responses relative to pet ownership in this community. We will compare IgE and IgG responses to cat and dog with Reponses to other allergens. 3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms.

描述（由申请人提供）：最近的证据表明，在某些社区，早期生活中暴露于家中的猫和狗可以防止过敏性致敏和哮喘。然而，这种宠物保护作用在市中心或儿童暴露于高水平蟑螂和小鼠过敏原的环境中尚未得到广泛研究。哥伦比亚儿童环境健康中心目前正在北方曼哈顿进行的一项出生队列研究为研究市中心社区的这一现象提供了一个理想的机会。我们假设，对于生活在市中心暴露于蟑螂和小鼠过敏原的儿童，在生命早期暴露于高浓度的猫和狗过敏原可降低发生宠物特异性IgE反应和过敏症状的风险。这一假设是基于在其他地方观察到的宠物所有权的保护作用，以及在没有主要过敏原尘螨的社区中报告的一般特应性保护作用的差异（例如，瑞典），但在螨种群数量较多的社区中未观察到（例如，新西兰）。具体目的旨在阐明高剂量猫和狗过敏原暴露在城市儿童过敏性疾病发展中的作用，通常暴露于蟑螂和小鼠过敏原： 1)在多个时间点确定家中宠物过敏原的水平，并使用问卷数据验证数据。这将使我们能够更好地量化累积的宠物过敏原暴露。 2)确定该社区中与宠物所有权相关的早期过敏原特异性抗体反应。我们将比较猫和狗的IgE和IgG反应与其他过敏原的反应。 3)确定宠物过敏原暴露于市中心社区是否与过敏性疾病和哮喘的早期预测因素相关，包括持续性喘息，医生诊断的湿疹和哮喘症状。