A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

项目摘要 整体 UAB CFAR的使命是支持基础科学，治疗学， 艾滋病毒的预防、社区参与的研究、临床表现和发病机制以及 紊乱五个核心设施为其科学议程的主要专题领域提供了重要支持。 为了优化我们的CFAR运营，密集的战略规划流程通过以下方式提高了效率： 将其核心从7个精简为5个，充分利用校园内其他中心提供的现有服务， 外包未充分利用的服务，并允许在新领域投资（具体目标讲习班， 移植组织采购设施，并结束艾滋病毒在亚拉巴马SWG）。该中心包括185名成员 来自UAB内部30多个部门和部门。在过去的4年里，UAB CFAR促进了研究 导致FRB /总资金为2100万美元/6600万美元。大多数（62%）是在本预算期间新获得的; 其中57%与基础科学有关，18%与人口健康预防和治疗研究有关，22%与 行为EPI和干预研究，3%的社区参与研究。自从我们上次续约以来， 中心已将获得培训奖支助的年轻调查员人数从7人增加到16人（14名妇女; 5个代表性不足的少数民族，URM），并投资190万美元用于新调查员试点奖励， 外部资金。总的来说，我们的投资回报率在试点资金是13：1在新的校外赠款授予。中心帮助 在过去4年中招募了45名新的艾滋病毒/艾滋病调查员（17名外部人员，28名新的艾滋病毒研究人员），其中21名是 妇女和5个统一登记机制。在所有核心中，CFAR支持了61个独特的NIH资助项目（FRB）和404个其他项目。 国家卫生研究所资助的项目，其中309个是专门针对艾滋病毒的项目，产生了1000多份艾滋病毒出版物， 强大的机构支持。在未来五年，我们将： (1)通过促进跨学科研究，继续提高正在进行的研究项目的生产力 通过提供关键的共享资源设施以及行政和财政管理支助， 中心研究人员（2）使用强大的战略规划方法来确定新的研究机会， 优先事项与现有的CFAR计划保持一致，并在没有新的研究计划的情况下促进新的研究计划， 但在教师的兴趣是明显的;（3）刺激进入早期阶段和建立教师对艾滋病毒/艾滋病 研究计划，通过指导计划，为年轻的研究人员，并通过一个强大的，同行评审 发展赠款计划;（4）为UAB的艾滋病毒/艾滋病研究活动提供一个中心焦点， 强调CFAR成员与更广泛的艾滋病毒/艾滋病研究之间的有效沟通和合作 社区;（5）促进教师招聘和项目发展的领域，反映了正在进行的 艾滋病毒/艾滋病研究在亚拉巴马，美国和世界各地的演变。 UAB CFAR将促进具有高度地方，国家和国际影响的艾滋病毒/艾滋病研究， 这样做将促进NIH在艾滋病治疗和预防方面的创新和有效性。

PROJECT SUMMARY Overall The mission of the UAB CFAR is to support the conduct of cutting-edge research in basic science, therapeutics, prevention, community engaged research, and clinical manifestations and pathogenesis of HIV and related disorders. Five core facilities provide vital support for the Center's principal thematic areas of its scientific agenda. To optimize our CFAR operation, an intensive strategic planning process has established efficiencies through streamlining its cores from 7 to 5, taking full advantage of existing services provided by other centers on campus, outsourcing under-utilized services, and allowing for investments in new areas (Specific Aims workshops, Transplant Tissue Procurement Facility, and Ending HIV in Alabama SWG). The Center includes 185 members from over 30 divisions and departments within UAB. Over the last 4 years, the UAB CFAR has enabled research leading to FRB / total funding of $21M / $66M. The majority (62%) was newly obtained in this budget period; 57% of these are related to basic science, 18% to population health prevention and treatment research, 22% to behavioral epi and intervention research, and 3% to community engaged research. Since our last renewal, the center has increased the number of young investigators supported by training awards from 7 to 16 (14 women; 5 under-represented minorities, URMs) and invested $1.9M in new-investigator pilot awards yielding $25M in outside funding. Overall, for our ROI in pilot funding is 13:1 in new extramural grants awarded. The Center helped recruit 45 new HIV/AIDS investigators in the last 4 years (17 external, 28 new to HIV research), of whom 21 are women and 5 URMs. Across all cores the CFAR supported 61 unique, NIH-funded projects (FRB) and 404 other NIH-funded projects, of which 309 were HIV-specific resulting in over 1000 HIV publications, and in the garnering of strong Institutional support. Over the next 5 years we will: (1) Continue to enhance the productivity of ongoing research programs by enabling interdisciplinary research through the provision of critical shared resource facilities and administrative and fiscal management support to Center investigators (2) Use robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence, but where faculty interest is evident; (3) Stimulate the entry of early stage and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and through a robust, peer-reviewed Developmental Grants Program; (4) Provide a central focus for HIV/AIDS research activities at UAB that emphasize effective communication and collaboration among CFAR members with the wider HIV/AIDS research community; and (5) Promote faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The UAB CFAR will foster HIV/AIDS research that has high local, national, and international impact and in so doing will promote the NIH priorities of innovation and effectiveness in AIDS treatment and prevention.