Preconceptional health of Latinas and its association with child adiposity

摘要： 西班牙裔儿童超重/肥胖的患病率高于非西班牙裔儿童 对口单位。围产期产妇的健康状况和生活方式行为被认为是 儿童肥胖的重要危险因素。孕前母亲肥胖与更高的 婴儿出生体重和后代肥胖风险增加。母体饮食与代谢 在先入为主的过程中的个人资料已被证明对随后的健康产生不利影响 后代，包括肥胖的发展。然而，拉美裔美国人的数据很稀缺 来自不同背景和有限，一般由于缺乏标准化 关于先入为主的健康的记录。西班牙裔社区健康研究 拉丁裔(HCHS/SOL)，来自美国四个国家的16,415名成年人(包括3,801名18-44岁的女性)组成的队列。 是美国最大的关于拉美裔/拉丁裔的健康研究。基线数据，包括 心脏代谢标志物和饮食，从2008年到2011年收集，生殖史是 2014年10月至2017年在走访2处领取。因此，HCHS/SOL提供了独特的 前瞻性调查未孕母亲健康状况的作用的机会 (心脏代谢生物标志物和饮食)对儿童肥胖发展的影响 了解暴饮暴食的驱动因素，如与食物奖励相关的行为和心理 妇女的压力作为婴儿喂养习惯和体重的预测因子。这项辅助研究 建议招募440名母子双胞胎；这些人是育龄妇女，有孩子 (3-7岁)自基线检查以来出生，以评估儿童的体重、身高和肥胖 (DEXA测量的总脂肪量)、饮食和其他生活方式行为，以及女性的食物 与奖励相关的行为。我们建议确定儿童体重的早期可修改决定因素 以及不能归因于遗传环境的肥胖状况。这是一种新的用法 有能力回答非常及时和重要的研究问题的现有队伍 在这一非常关键的时期为干预研究的发展作出贡献 西班牙裔人口的母亲和孩子的生命周期。

Abstract: Hispanic children have a higher prevalence of overweight/obesity than their non-Hispanic counterparts. Perinatal maternal health status and lifestyle behaviors are recognized as important risk factors for childhood obesity. Pre-pregnancy maternal obesity is linked to higher infant birth weight and increased risk of offspring obesity. The maternal diet and metabolic profile during preconception has been shown to adversely affect the subsequent health of the offspring, including the development of obesity. However, the data are scarce for Hispanics from various backgrounds and limited, in general, due to the lack of standardized documentation of preconception health. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 adults (including 3,801 women 18-44y) from four U.S. cities, is the largest health study of Hispanics/Latinos in the US. Baseline data, including cardiometabolic markers and diet, were collected from 2008 to 2011, and reproductive history is being collected at visit 2 from October 2014 to 2017. Hence, HCHS/SOL offers a unique opportunity to prospectively investigate the role of preconceptional maternal health status (cardiometabolic biomarkers and diet) on the development of childhood obesity and to understand drivers of overeating, such as food reward-related behaviors and psychological stress of women as predictors of child feeding practices and weight. This ancillary study proposes to recruit 440 mother-child dyads; these are women of reproductive age with a child (ages 3-7y) born since the baseline examination to assess child's weight, height and adiposity (total fat mass as measured by DEXA), eating and other lifestyle behaviors, and women's food reward-related behaviors. We propose to identify early modifiable determinants of child's weight and adiposity status that are not attributable to the genetic environment. This is a novel use of an existing cohort to answer very timely and important research questions that have the ability to contribute to the development of intervention studies during this very critical time period in the lifecycle of both the mother and child for the Hispanic population.