Administrative Core

项目总结 该计划的目的是召集一组调查人员，专注于两种疾病的病理生物学 重要疾病状态、慢性同种异体肺移植功能障碍和特发性肺纤维化 最先进的动物模型和人体样本。该计划的目标是改善我们的 了解疾病进展的机制并确定新的治疗靶点 以对抗肺纤维化，无论是发生在呼吸道还是发生在肺间质。该计划带来了 一个由拥有互补技能的科学家和内科科学家组成的团队，作为一个整体在这些方面工作 重要的问题。为了协调这些努力，我们提出了一个行政核心，以促进 互动和遵守NIH关于PO1提案管理的规定。我们建议 以下是具体目标： 协调和促进项目负责人和核心负责人之间的项目管理。 在内部和外部调查人员之间协调和促进项目的管理 为最大限度地提高科学生产力而组织的顾问和丰富计划。

PROJECT SUMMARY The purpose of the Program is to bring together a team of investigators to focus on the pathobiology of two important disease states, Chronic Lung Allograft Dysfunction and idiopathic pulmonary fibrosis using both state-of-the-art animal modeling and human samples. The goals of this Program are to improve our understanding of the mechanisms that contribute to disease progression and identity novel therapeutic targets to combat lung fibrosis whether it occurs in the airway or in the interstitium of the lung. The Program brings together a team of scientists and physician scientists with complementary skills to work as a unit on these important problems. In order to coordinate these efforts, we propose an Administrative Core to facilitate interactions and adherence to NIH regulations regarding management of PO1 proposals. We propose the following Specific Aims:  Coordinate and facilitate administration of the Program between Project Leaders and Core Leaders.  Coordinate and facilitate administration of the Program between investigators, internal and external advisors and an enrichment program organized to maximize scientific productivity.