Research Core Methods

研究方法核心C 方法核心将提供统计分析技术、研究设计、心理健康和社会科学方面的服务和培训。 健康测量和数据管理。与迈阿密大学发展艾滋病 研究中心（UM D-ARC）的重点是减少心理健康和少数民族健康的影响 艾滋病毒预防和护理方面的差距我们继续注重多层次的方法。MH co- 发病率本质上是个体水平的过程。相比之下，MH和少数民族的健康差距是由 通过存在于各个层面的更高层次的结构性社会文化过程（例如，社区，城市， 区域）内的个体嵌套。因此，中心研究者的干预措施和方法 可能既涉及个人，也涉及这些社会文化进程，因此是多层次的。 方法核心有三个目标。目标1：促进使用适当的最新科学技术 多层次研究中的研究设计和统计方法，将为地方实施提供信息， 符合UM D-ARC主题和目标的循证实践。实现这一目标的活动 将包括为HIV/AIDS MH研究人员提供咨询，制定NIH赠款提案（以及 获奖后的支持），并支持研究领域的UM-ARC试点研究的早期研究者 HIV及其合并症的生物标志物的设计、使用和统计分析策略。目标2：创造， 维护并促进使用集中数据库和仪器库，作为以下方面的资源： 对MH和少数民族在艾滋病毒/艾滋病方面的健康差距进行了高影响力研究。这将包括自愿 统一的数据架构，包括通用数据元素，以促进协作和合作 以创新的新方式利用D-ARC数据的项目，以及包括西班牙语和西班牙语的REDCap仪器库， 海地克里奥尔语措施。我们将提供现有的电子数据收集表格， 关于如何为新措施制作新的电子数据收集表格的说明。目标3：提供 分流访问其他UM D-ARC核心资源以及国家的科学方法 补充和扩大现有大学资源的讲习班和其他能力建设活动 重点关注艾滋病毒/艾滋病中的MH差异。支持这一目标的活动包括建立一个全面的 研究导航平台，用于协调D-ARC方法咨询和所有中心 资源;并举办以新方法为重点的讲习班，内容涉及多级建模、GIS制图 MH结局，确定亚组和估计治疗效果异质性的方法， 实施研究和模型选择方法。核心小组还将促进协商， 来自其他D-ARC核心和附属研究小组的演讲，如CFAR，CTSI，NIDA的 国家药物滥用治疗临床试验网络和NIDA的P30 CHERISH中心，该中心专注于 成本效益分析。

Project Summary Research Methods Core C The Methods Core will provide services and training in statistical analysis techniques, research design, mental health (MH) measurement, and data management. With the University of Miami Developmental AIDS Research Center (UM D-ARC)’s emphasis on Reducing the Impact of Mental Health and Minority Health Disparities across the HIV Prevention and Care Continua we focus on multi-level methods. MH co- morbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g. neighborhoods, cities, regions) within which the individual is nested. Therefore, interventions and approaches of center investigators are likely to address both individuals as well as these socio-cultural processes and, thus, be multi-level. The Methods Core has three aims. Aim 1: To promote use of appropriate state-of-the-science research design and statistical methods in multi-level research that will inform local implementation of evidence-based practice consistent with the UM D-ARC theme and goals. Activities to address this aim will include providing consultation to HIV/AIDS MH researchers developing NIH grant proposals (as well as post-award support) and supporting early stage investigator with UM-ARC pilot studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and statistical analysis strategies. Aim 2: To create, maintain, and facilitate use of a centralized data repository and an instrument library as resources for high-impact research on MH and minority health disparities in HIV/AIDS. This will include a voluntary unified data architecture that includes common data elements to facilitate collaboration and cooperative projects to utilize D-ARC data in innovative new ways and a REDCap instrument library including Spanish and Haitian Creole-language measures. We will provide access to existing electronic data collection forms and instruction on how to create new electronic data collection forms for new measures. Aim 3: To provide triaged access to other UM D-ARC Core resources as well as state-of-the science methodology workshops and other capacity-building activities that complement and expand existing UM resources to focus on MH disparities in HIV/AIDS. Activities to support this aim include creation of a comprehensive Research Navigation Platform to coordinate access to D-ARC methodology consultations and all Center resources; and conducting new methods-focused workshops with content on multilevel modeling, GIS mapping of MH outcomes, methods for identifying subgroups and estimating treatment effect heterogeneity, approaches to implementation research, and model selection approaches. The Core will also facilitate consultations and presentations from other D-ARC cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.