Research Infrastructure Core

研究基础设施核心 摘要 前列腺癌是美国男性癌症死亡的第二大原因，仅次于肺癌。在 非洲裔男性，前列腺癌发病率高出65%，死亡率超过 与高加索人相比，两倍。造成这种发病率和死亡率种族差异的原因是， 非洲裔美国人知之甚少，但可能涉及生物和环境因素。的 克拉克亚特兰大大学（CAU）的癌症研究和治疗开发中心（CCRTD）是 致力于一个持续的方法，以加强全面的研究计划，调查 细胞和遗传因素参与前列腺癌的发生、发展和转移 本提案中提出的研究和试点项目。为了支持研究和试点项目， “研究基础设施核心”将为5个具有最先进仪器的功能性核心实验室提供支持 及相关服务。此外，还将建立一个动物核心实验室，为项目负责人提供当地的 优质的动物护理和先进的动物研究。最后，将提供强化培训，以确保 项目负责人和其他用户熟悉核心设备的应用。最后 研究基础设施核心将是研究和试点项目的宝贵资源， 更大的研究社区，提供最先进的仪器，并确保成功的建议 research.

Research Infrastructure Core Abstract Prostate cancer is the second leading cause of cancer deaths among American men after lung cancer. In African-American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate in African-Americans are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University (CAU) is committed to an on-going approach to enhance the comprehensive research program to investigate the cellular and genetic factors involved in initiation, progression and metastasis of prostate cancer through three research and pilot projects proposed in the current proposal. In order to support the research and pilot projects, the Research Infrastructure Core will support five functional Core Laboratories with state-of-the-art instruments and related services. Moreover, an Animal Core Laboratory will be created to provide project leaders with local quality animal care and advance animal research. Lastly, enhanced training will be provided to ensure that project leaders and other users are acquainted with the application of core equipment. In conclusion, the Research Infrastructure Core will be an invaluable resource to the research and pilot projects, as well as the larger research community, to provide state-of-the-art instrumentation, and ensure the success of the proposed research.