A Behavioral Intervention to Engage Emerging Adults in Addiction Treatment after a Non-fatal Opioid Overdose

项目总结 与阿片类药物有关的过量死亡继续以惊人的速度攀升--自2000年以来超过200%。新兴 成年人(18-25岁的个人)是阿片类药物流行的关键人群，尤其是 参与治疗很重要，因为它们占越来越高的绝对和相对死亡率 阿片类药物过量。成年初期是一个不同的发育阶段，因此这些治疗参与 应该根据发展情况量身定做工作。此应用程序描述了一项为期5年的以患者为中心的指导 研究和培训计划，以开发以参与高风险新出现的行为为重点的行为干预 成人在向急诊科提出非致命的过量用药后需要接受治疗。建议数 干预模式是基于动机干预，通过提高自我效能感来降低服药过量风险。 最近有非医疗使用阿片类止痛药史的成年人。我的职业目标是成为一名 独立的临床医生调查员，在行为干预开发和测试方面具有专业知识 患有阿片类药物使用障碍的新兴成年人。此应用程序的具体目标是1)量化时间以 成瘾治疗或反复服药过量用于经历非致命性服药过量的新兴成年人，2)使用 为经历非致命性疾病的新兴成年人提供干预发展信息的定性方法 3)进行一项试点试验，以确定干预的可行性和后勤保障。我的教育 目标是学习：1)行为干预发展，2)新兴的行为改变科学 成人；3)临床试验设计。我已经确定了一支备受尊敬的指导团队和一位支持我的 帮助我实现目标的环境。这项工作的结果将使我能够提交R01赠款到 进行一项干预措施的全面疗效试验，以减少过量用药的危险行为并增加 非致命性过量用药的新发成人的治疗参与度。

PROJECT SUMMARY Opioid-related overdose deaths continue to climb at alarming rates – greater than 200% since 2000. Emerging adults (individuals aged 18-25 years old) are a key demographic in the opioid epidemic, and especially important to engage in treatment, as they account for increasingly high absolute and relative rates of fatal opioid overdoses. Emerging adulthood is a distinct developmental stage and so these treatment engagement efforts should be developmentally tailored. This application describes a 5-year patient-oriented mentored research and training plan to develop a behavioral intervention focused on engagement of high risk emerging adults to treatment after they present to the emergency department with a nonfatal overdose. The proposed intervention model is based on a motivational intervention to reduce overdose risk by improving self-efficacy in adults who have a history of recent nonmedical use of opioid analgesics. My career goal is to become an independent clinician investigator with an expertise in behavioral intervention development and testing for emerging adults with opioid use disorders. The specific aims of this application are to 1) quantify the time to addiction treatment or recurrent overdose for emerging adults who experience a nonfatal overdose, 2) use qualitative methods to inform intervention development for emerging adults who experience a nonfatal overdose, and 3) conduct a pilot trial to determine feasibility and logistics of the intervention. My educational objectives are to learn: 1) behavioral intervention development, 2) science of behavior change in emerging adults, and 3) clinical trial design. I have identified a well-respected mentoring team and a supportive environment to help me achieve my goals. The results from this work will position me to submit a R01 grant to conduct a fully-powered efficacy trial of an intervention to reduce overdose risk behaviors and increase treatment engagement among emerging adults with non-fatal overdose.