Pacific Northwest Center for Translational Environmental Health Research

总体汇总 环境健康科学的一个主要范式是不良后果途径。不良后果 路径包含外部段和内部段。外部部分是一种有毒化学物质， 会接触到一个人这种化学物质可能来自空气、水、土壤或饮食。的内部区段 结果途径的一个组成部分是一系列事件：化学品与生物靶点相互作用， 触发事件，进而导致器官反应，有机体反应和群体反应。这 框架支持我们这个时代最重要的环境健康科学问题：什么化学物质 暴露会导致疾病吗它们是如何致病的？为什么有些人比其他人更容易受到影响？如何 我们能预测毒性吗我们如何减轻危险化学品的影响？我们怎样才能减少 有毒化学品的危害吗为了回答这些问题，OSU EHS CC拥有一个世界领先的 在世界上两个最强大的技术研究不良后果途径的立场。到 为了研究外部部分，化学品暴露（CXC）设施核心开发了被动采样 捕捉挥发性和半挥发性有机化学品的腕带，以及可以 以低成本在单次运行中检测和定量1，500种化合物。为了研究内部部分，斑马鱼 生物医学研究（ZBR）设施核心已经建立了世界上最大的无特定病原体（即，表示“低”之义 实验噪声）斑马鱼环境健康科学设施。机器人评估运动活动， 寻找身体和行为的终点全基因组转录组学分析揭示了 表达在表型改变之前改变。CXC和ZBR一起为我们的调查人员提供了 在EHS领域拥有独一无二的强大实验能力。此外，这些技术比 互补;它们是协同的。我们已经将腕带提取物作为直接输入应用于斑马鱼 生物测定法，并通过效应导向分析确定化学混合物中毒性最大的化合物。我们 综合健康科学设施和社区参与核心将使这些能力可用 通过一种新的转化研究模式扩展到EHS社区。我们计划共同生产知识 与七类利益相关者（居民社区、立法者、监管者、制造商、卫生 护理提供者、制药公司和非营利组织）。EHS CC成员将进行交叉- 与这些利益攸关方进行部门多学科研究，以产生可采取行动的科学证据， 指导利益攸关方做出改善环境公共卫生的决策。

OVERALL SUMMARY A dominant paradigm of environmental health science is the adverse outcome pathway. The adverse outcome pathway contains an external segment and an internal segment. The external segment is a toxic chemical that comes into contact with a person. That chemical may come from air, water, soil, or diet. The internal segment of the outcome pathway consists of a chain of events: the chemical interacts with a biological target, which triggers events that in turn lead to organ responses, organism responses, and population responses. This framework supports the most important environmental health science questions of our era: What chemical exposures cause disease? How do they cause disease? Why are some people more susceptible than others? How can we predict toxicity? How can we mitigate the impacts of hazardous chemicals? How can we reduce the use of toxic chemicals in commerce? To answer these questions, the OSU EHS CC has an established world-leading position in two of the world's most powerful technologies for investigating the adverse outcome pathway. To study the external segment, the Chemical Exposure (CXC) Facility Core has developed passive sampling wristbands that capture volatile and semi-volatile organic chemicals, as well as analytical techniques that can detect and quantify 1,500 compounds in a single run at low cost. To study the internal segment, the Zebrafish Biomedical Research (ZBR) Facility Core has built the world's largest specific-pathogen-free (i.e., low- experimental-noise) zebrafish environmental health sciences facility. Robots evaluate locomotor activity and look for physical and behavioral endpoints. Full-genome transcriptomics analyses reveal which gene expressions change before the phenotype changes. Together, the CXC and the ZBR give our investigators uniquely powerful experimental capabilities in EHS. Furthermore, these technologies are more than complementary; they are synergistic. We have applied wristband extracts as direct input to the zebrafish bioassay and identified the most toxic compounds in chemical mixtures via effects-directed analysis. Our Integrated Health Sciences Facilities and Community Engagement Cores will make these capabilities available to the extended EHS community via a new translational research model. We plan to co-produce knowledge with stakeholders in seven categories (residential communities, legislators, regulators, manufacturers, health care providers, pharmaceutical firms, and non-profit organizations). EHS CC members will conduct cross- sectoral multidisciplinary research with these stakeholders in order to generate actionable scientific evidence to guide stakeholder decisions that will improve environmental public health.