Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) of the Cooperative Human Tissue Network (CHTN)

项目摘要/摘要 该提案组织了阿巴拉契亚和五大湖研究的资源和经验 生物样品资源(AGL-RBR)，作为NCI合作人体组织的成人部参加 网络(CHTN)。我们的AGL-RBR病理学家团队有能力有效地为残存患者提供 同意用于基础和早期转化性癌症研究以及生物标记物研究的生物样品 支持个性化医疗的研究。俄亥俄州立大学(OSU)医院和詹姆斯癌症 俄亥俄州哥伦布市的医院将作为协调/采购中心，而大学医院 克利夫兰医疗中心，俄亥俄州克利夫兰，布法罗大学附属医院，纽约州布法罗和大学 宾夕法尼亚州匹兹堡沙德赛德匹兹堡医疗中心及其附属医院将作为 地理上分散的采购/生物库站点。俄亥俄州立大学协调中心--调查员 管理处将管理调查员申请和批准以及调查员生物检疫。 请求联网。俄亥俄州立大学生物制品管理处将负责组织质量控制， 生物制品的储存和运输以及CHTN费用的计费、收款和月度核算。组织 采购支持定制生物样品收集，包括调查人员提供的新型保存液 或方法。现有的信息学支持收集与捐赠者同意、生物检疫、 调查人员和账单。运送的生物样品包括每种生物样品的编辑后的病理和质量控制报告 生物素已装船。俄亥俄州立大学新获得的组织的病理学报告包括临床上合适的 分子测试。如果IRB批准，调查人员还可以要求从 OSU信息仓库(IW)和其他实验室测试，如免疫组织化学、组织 微阵列构建、数字显微镜或数字形态计量学。Biosecimen捐赠者隐私和 保密性是AGL-RBR生物检疫管理提案的基本要素，以便所有采购的 生物标记物是患者同意和编码的。脱链可用于特殊的组织，而不是 在采购时同意。俄亥俄州立大学采购计划加入了俄亥俄州立大学综合癌症中心 (OSUCCC)在2016年部署全面癌症护理®(TCC)方案，为全面的捐赠者提供 同意。同意的捐赠者将充分利用他们过去、现在和未来的所有残留物进行未来的研究 生物材料向IRB批准的研究人员。采购/生物库网站在 地点。在我们的组织中获得的科学或技术知识或发现 采购/保存计划将在国家和国际科学和技术会议上报告 为促进生物科学的发展而召开的会议，招募有研究能力的新研究人员 最有利于人类生物研究的利益，并向研究界和公众提供信息。

PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) for participation as an Adult Division of the NCI Cooperative Human Tissue Network (CHTN). Our AGL-RBR group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, University at Buffalo hospital affiliations, Buffalo, NY and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Coordinating Center- Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections and monthly accounting. Tissue Procurement supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology Reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may also request, if IRB approved, extensive clinical data available from the OSU Information Warehouse (IW) and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the AGL-RBR biospecimen management proposal so that all procured biospecimens are patient consented and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the Total Cancer Care® (TCC) protocol in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research all of their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository sites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.