Biostatistics and Informatics Facility Core

综合环境健康科学中心(CIEHS)的长期目标是建立 综合研究污染物联合暴露与生活方式相互作用的框架 因素)，以了解它们在人类健康和不同生命阶段的疾病风险中的作用 按性别修改。生物统计和信息学设施核心(BIFC)在支持 通过为所有CIEHS提供最先进的统计和生物信息学支持和培训来进行CIEHS研究 会员。BIFC是设计系统的临床前采集和沉积的必要资源 以及提供严格的数据分析所需的智力输入。建造 整合关于污染和生活方式影响因素的翻译基础科学研究的框架 慢性病风险需要复杂的统计支持。BIFC通过使用以下状态来满足这一需求 与统计和信息学相关的艺术技术，因为它在CIEHS成员的所有阶段为其服务 学习。BIFC为CIEHS成员研究提供无缝基础设施和支持，包括 临床前-基础科学，以患者为中心的临床研究(例如，诊断、预防和治疗 环境相关疾病)、公共卫生/以人口为基础的研究和社区参与/ 社区主导的研究。北京国际金融中心的目标是：1.在设计方面提供最先进的统计支持， 分析和传播一系列基础科学、翻译、临床、人口健康和 环境流行病学研究；2.为整合来自两种动物的多组学数据提供支持 和人体研究；3.促进暴露数据与生活方式因素的整合，以确定影响因素 和环境暴露对健康影响的调解人；4.教育中心调查人员、工作人员和 受训人员学习适用于其研究活动的与统计/组学方法有关的新方法。范围： 特殊兴趣包括重复测量模型、测量误差、时空方法 计算生物学、统计遗传学、临床信息学和贝叶斯方法。几个CIEH 成员目前使用BIFC主任和工作人员的统计支持服务，表明两者都有需求 和富有成效的互动。向肯塔基州生物医学研究基础设施网络和 INBRE为一些BIFC生物信息学人员提供部分支持，并访问各种 生物信息学和统计工具。通过利用和利用UofL的现有资源，BIFC 能够方便CIEHS成员访问和使用这些资源，并扩大统计和 以更具成本效益的方式提供生物信息学支持。

The long-term objective of the Center for Integrated Environmental Health Sciences (CIEHS) is to build a framework that integrates studies on the interactions between combined exposure to pollutants and life style factors), in order to understand their role in human health and disease risk at various life stages and as modified by gender. The Biostatistics and Informatics Facility Core (BIFC) plays a vital role in supporting CIEHS research by providing state-of-the-art statistical and bioinformatics support and training to all CIEHS members. The BIFC is an essential resource for designing systematic acquisition and deposition of preclinical and clinical data as well as for providing intellectual input required for rigorous data analysis. Building the framework to integrate translational basic science research on pollution and lifestyle cofactors influencing chronic disease risk requires sophisticated statistical support. The BIFC addresses this need by using state-of- art techniques related to statistics and informatics as it serves CIEHS members during all phases of their studies. The BIFC provides seamless infrastructure and support to CIEHS member research, including preclinical-basic science, patient-oriented clinical research (e.g., the diagnosis, prevention, and therapy of environmentally-related disorders), public health/population-based research, and community-engaged / community-led research. The aims of the BIFC are: 1. Provide state-of-the-art statistical support in design, analysis and dissemination of findings of a range of basic science, translational, clinical, population health and environmental epidemiology studies; 2. Provide support for the integration of multi-omics data from both animal and human studies; 3. Facilitate integration of exposure data with lifestyle factors to identify effect modifiers and mediators of the health effects of environmental exposures; 4. Educate center investigators, staff and trainees in new methods related to statistics/omics approaches applicable to their research activities. Areas of special interest include, repeated measures models, measurement error, spatio-temporal methods, computational biology, statistical genetics, clinical informatics and Bayesian methods. Several CIEHS members currently use the statistical support services of the BIFC Director and staff, demonstrating both need and productive interactions. An IDeA grant to the Kentucky Biomedical Research Infrastructure Network and INBRE provides partial support for some BIFC bioinformatics personnel and access to a variety of bioinformatics and statistical tools. By leveraging and building upon existing resources at UofL, the BIFC is able to facilitate access and use of these resources by CIEHS members and expand statistical and bioinformatics support in a more cost efficient manner.