Preclinical Core Component 3

项目总结 临床前核心支持大脑恢复和修复中心的使命，通过提供良好的 使用临床前模型对研究人员进行结构和功能改变的验证测量 神经紊乱。核心是一个集中资源，提供智力指导、技术专长、 用于高质量自动化行为和结构分析的培训和仪器，广泛适用 研究了一系列大脑和行为疾病的临床前模型。通过培养新的研究人员 青年研究人员和知名专家之间的计划和协作互动，核心有 在提高新墨西哥州大学脑损伤和修复研究的卓越水平方面发挥了重要作用。总体而言，目标是 的核心是利用我们在第一阶段的成功，将临床前研究能力迅速提升到临界量 资助的调查人员需要支持中心的自我可持续发展的使命，而不仅仅是想法层面的资金。 我们将继续提供所需的资源和专业知识，以支持跨学科的前沿 该项目主要研究大脑恢复和修复的神经生理机制，并 通过项目开发和战略部署，扩大我们新老调查人员的用户基础 对最先进的仪器、途径和方法进行投资。通过培养创新能力 新的研究计划和初级调查人员与现有研究人员之间更多的协作互动 科学家核心将为大脑恢复和修复中心作为全国可持续发展做出贡献 被公认为脑康复领域翻译研究的领导者。自2015年成立以来，临床前 CORE通过引领将翻译脑电作为评估平台的开发，帮助推动了该领域的发展 跨物种行为中神经活动的同源性。第二阶段建立在这些成功的基础上， 结合了生理和行为方法，并增加了更高的吞吐量解剖评估 利用先进的共聚焦成像技术加速研究。从第一阶段开始，核心将促进 加速项目轨迹的中心使命导致独立的NIH-R01水平资金用于 初级调查人员或更高级的调查人员在脑损伤领域确立自己的地位。这个 临床前核心将继续促进临床和临床前研究人员之间的多学科互动 在新墨西哥州大学和西部山区的另一边。我们还将为发现新的治疗方法提供平台 使用临床前模型进行大脑恢复和修复的途径将提高整体卓越水平 在神经科学研究的这个重要领域。

PROJECT SUMMARY The Preclinical Core supports the mission of the Center for Brain Recovery and Repair by providing well- validated measures of both structural and functional alterations for investigators utilizing preclinical models of neurological disorders. The Core is a centralized resource providing intellectual guidance, technical expertise, training and instrumentation for high quality automated behavioral and structural analyses, broadly applicable across a range of preclinical models of brain and behavioral illnesses. Through cultivation of new research programs and collaborative interactions between young investigators and established experts, the Core has played an essential role in elevating the excellence of brain injury and repair research at UNM. Overall, the goal of the Core is to leverage our success in Phase I to catapult preclinical research capacity to the critical mass of funded investigators required to support the Center’s mission of self-sustainability beyond IDeA-level funding. We will continue to provide the resources and expertise required to support interdisciplinary cutting-edge research projects of Project Leads in neurophysiological mechanisms of brain recovery and repair, and to expand our user base of new and established investigators through project development and strategic investment in state-of-the-art instrumentation, approaches and methodologies. Via the cultivation of innovative new research programs and increased collaborative interactions between junior investigators and established scientists the Core will contribute to the sustainability of the Center for Brain Recovery and Repair as a nationally recognized leader for translational research in brain recovery. Since being established in 2015, the Preclinical Core has helped advance the field by leading in the development of translational EEG as a platform for assessing homology of neural activity during behaviors across species. Phase II builds on these successes with the combination of physiological and behavioral approaches, and adds higher throughput anatomical assessments to speed studies utilizing sophisticated confocal imaging. Continuing from Phase I, the Core will promote the Center mission of accelerating the trajectory of Project Leads toward independent NIH-R01 level funding for Junior Investigators or establishing themselves in the field of brain injury for more senior Investigators. The Preclinical Core will continue to foster multidisciplinary interactions between clinical and preclinical investigators at UNM and across the Mountain West. We will also provide a platform for the discovery of novel therapeutic avenues for brain recovery and repair using preclinical models that will enhance the overall level of excellence in this vital area of neuroscience research.