Component for Institution # 264313

天普大学NIDA P30中心与成瘾相关行为的动物核心Will 支持美国国立卫生研究院资助的使用体内啮齿动物模型的合作研究项目，以推动 关于滥用药物、成瘾药物、疼痛药物以及滥用药物与 艾滋病毒/艾滋病。核心的一个目标是提供科学专门知识、人员、设备和其他 评估药物强化、奖励、恢复和相关工作所需的资源 需要严格评估的大鼠和小鼠的认知和情绪功能终点 潜在的新的治疗化合物和靶点，以及阐明神经生物学机制 潜在的上瘾。核心的另一个目标是为P30协作提供突变的啮齿动物模型 研究人员，以便能够研究体内的特定分子和途径。在一个农场里饲养动物 中央设施降低了费用，并促进了这些有价值的型号对多个 研究人员。核心人员将与调查人员合作设计实验，包括强调 关于适当的控制、数据分析和结果解释。如果合作者提出要求， 动物核心将提供行为方法方面的培训，或者核心工作人员将执行测试 独立的。核心提供以下方法：静脉和口服药物和乙醇自我 给药，对食物或蔗糖的反应，条件位置偏爱和厌恶， 颅内自我刺激、学习和记忆评估、焦虑和抑郁样行为 测试，使用压力模型和其他必要的方法。新的创新行为评估和 本次更新应用中提出了动物模型，以增强研究的影响力 由成瘾相关行为动物核心支持。其中包括应用 药物自我给药研究的行为经济学方法和间歇性访问范式， 超声发声测量评估行为过程中的积极和消极影响 测试、培育转基因Cre大鼠，支持人源化的HIV-1感染小鼠模型。 核心作为国家资源，提供必要的知识、技能和设备 加强研究项目，并促进国家卫生研究院资助的项目的扩展，包括行为 与药物滥用研究相关的终点和动物模型。

The Animal Core for Addiction Related Behaviors of the NIDA P30 Center at Temple University will support collaborative NIH-funded research projects using in vivo rodent models in order to advance scientific knowledge on drugs of abuse, addiction, pain and the intersection of drugs of abuse with HIV/AIDS. One aim of the Core is to provide the scientific expertise, personnel, equipment and other resources that are necessary to assess drug reinforcement, reward, reinstatement, and related endpoints of cognition and emotional function in rats and mice as needed to rigorously evaluate potential new therapeutic compounds and targets, as well as to elucidate neurobiological mechanisms underlying addiction. Another aim of the Core is to provide mutant rodent models to P30 collaborating investigators in order to enable study of specific molecules and pathways in vivo. Breeding animals in a central facility reduces the expense and promotes access of these valuable models to multiple researchers. Core personnel will work with investigators to design experiments including an emphasis on appropriate controls, data analysis, and result interpretation. If requested by collaborators, the Animal Core will provide training in behavioral methods, or Core staff will perform the tests independently. The Core offers the following approaches: intravenous and oral drug and ethanol self- administration, operant responding for food or sucrose, conditioned place preference and aversion, intracranial self-stimulation, learning and memory assessments, anxiety- and depression-like behavioral tests, use of stress models and other methods as needed. New innovative behavioral assessments and animal models are proposed in this renewal application in order to enhance the impact of the research supported by the Animal Core for Addiction Related Behaviors. These include the application of behavioral economic methods and intermittent access paradigms to drug self-administration studies, measurements of ultrasonic vocalization to assess positive and negative affect during behavioral testing, breeding of transgenic Cre rats, and support of humanized mouse models of HIV-1 infection. The Core serves as a national resource by providing the knowledge, skills and equipment necessary to enhance research programs and to promote extension of NIH-funded projects to include behavioral endpoints and animal models relevant to substance abuse research.