Center on Intersystem Regulation by Drugs of Abuse

描述(由申请人提供)：我们要求对我们的NIDA P30中心进行为期5年的竞争性续签，支持现有的6个核心(行政、动物、生化药理学、细胞和免疫学、综合药理学和分子生物学)，并增加第七个核心，即数据库和药物相互作用核心。自成立以来，P30中心提高了生产力、协同性和多学科研究，并使药物滥用领域招聘新的教师成为可能。我们中心的主要综合主题包括1)神经免疫药理学，包括滥用药物对艾滋病毒的影响的研究，2)滥用药物，特别是阿片和大麻类药物，在调节炎症、疼痛、体温、强化和免疫功能方面的研究，以及3)药物相互作用的研究，这是至关重要的，因为个人很少滥用一种药物。新的方向包括更加重视大麻类物质，以及对滥用药物和艾滋病毒之间的关系进行更多研究。该中心正在进行的和未来的项目的范围结合了体内和体外的方法，在细胞、生化、分子和整个生物体水平上检查药物的效果。从行为测量到基因激活的各种信息的整合刺激了合作，导致了新的假设和结果。P30中心的核心促进了多学科的互动，导致了真正的智力整合和协同，导致了假设的建立和实验路线的实施，这是以前没有设想的。由P30核心支持的协作研究的结果确实具有创新性。该中心也是培训学生、博士后研究员和初级教师的中心。天普大学对该中心做出了重大承诺，将在未来维持药物滥用研究领域的增长。该中心是将目前由NIH或其他联邦或非联邦来源资助的调查人员聚集在一起的粘合剂，并以具有成本效益的方式增强和扩大与药物滥用和成瘾有关的研究的有效性。CSAR成员正在进行的尖端研究通过利用核心提供的专门知识、方法和技术得到支持和加强。

DESCRIPTION (provided by applicant): We are requesting a 5-year competing renewal of our NIDA P30 Center with support for the 6 current Cores (Administrative, Animal, Biochemical Pharmacology, Cell and Immunology, Integrative Pharmacology, and Molecular Biology) and the addition of a seventh, the Database and Drug Interactions Core. Since its inception, the P30 Center has enhanced productivity, synergy, and multidisciplinary research, and enabled the recruitment of new faculty into the field of drugs of abuse. Major integrative themes of our Center include 1) Neuroimmunopharmacology including the study of the effects of drugs of abuse on HIV, 2) Study of drugs of abuse, particularly opioids and cannabinoids, in regulation of inflammation, pain, body temperature, reinforcement, and immune function, and 3) Drug interaction studies which are vital because individuals rarely abuse a single drug. New directions include increased emphasis on cannabinoids and additional studies on the relationship between drugs of abuse and HIV. The scope of the ongoing and future projects in the Center marries in vivo and in vitro approaches that examine effects of drugs at the cellular, biochemical, molecular and whole-organism levels. Integration of information ranging from measurements of behavior to gene activation has stimulated collaborations leading to novel hypotheses and results. The Cores of the P30 Center have fostered multidisciplinary interactions resulting in a true intellectual integration and synergy leading to hypothesis building and implementation of lines of experimentation not previously conceived. The results from the collaborative studies supported by the P30 Cores have been truly innovative. The Center also is a focus for training students, postdoctoral fellows, and junior faculty. Temple University has made major commitments to the Center that will sustain growth in the area of drug abuse research in the future. The Center is the glue that brings together investigators currently funded by NIH or other Federal or non-Federal sources and enhances and extends the effectiveness of research related to drug abuse and addiction in a cost-efficient manner. Cutting edge research being conducted by members of CSAR is supported and enhanced by utilizing the expertise, methodologies, and techniques provided by the Cores.