Optimizing a Mindfulness-Based Intervention for Poor Sleep Quality During Pregnancy

项目总结/摘要 睡眠质量差在怀孕期间非常普遍，并且与许多风险增加有关。 对产妇的心理和健康产生不利影响。尽管如此，关于干预措施的研究有限， 改善怀孕期间的睡眠。此外，先前的研究并没有针对造成这种情况的独特因素。 这一人群睡眠质量差，如不适和疼痛。基于正念的干预措施，例如 基于正念的分娩和养育（MBCP），特别适合改善心理健康。 对不适和疼痛的反应，孕妇更喜欢非药物干预， 担心副作用。然而，缺乏优化和评估正念的研究- 以改善产前睡眠质量。为此，拟议项目将优化MBCP， 改善产前睡眠质量（MBCP-PS）并进行试点测试。候选人将使用最先进的 经验抽样方法，以确定夜间身体症状的心理反应， 与怀孕期间睡眠质量差密切相关。根据这些调查结果和来自 候选人将选择MBCP组件，以最大限度地影响已确定的目标。最后， 候选人将进行MBCP-PS与常规治疗的随机对照试验， 调查安全性、可接受性、依从性和可行性，并检查 对夜间身体症状的心理反应，以及与睡眠质量的关系。发现将 为R61/R33应用提供初步数据，以进一步优化MBCP-PS，并进行充分的 有把握的随机对照试验以病人为导向的研究职业发展 Award（Parent K23）提供以下方面的实质性实践经验和培训：1）交付和研究 正念为基础的和其他身心干预，2）机制为重点的干预发展和 分析，3）妇女围产期健康，和4）睡眠生理，评估和干预。候选 将在一个出色的研究环境中开展拟议的工作。她已经组装了一个 由知名导师和专业顾问组成的卓越团队，在这些主题上具有深厚的专业知识， 指导她提出的项目，并有专人致力于她的职业发展。该奖项将 为候选人提供建立独立研究计划所需的深入经验 专注于优化和评估基于正念的干预措施，以促进妇女的健康， 围产期

PROJECT SUMMARY/ABSTRACT Poor sleep quality is highly prevalent during pregnancy, and is associated with increased risk of numerous adverse maternal psychological and health outcomes. Despite this, there is limited research on interventions to improve sleep during pregnancy. Further, prior research has not targeted the unique factors contributing to poor sleep quality in this population, such as discomfort and pain. Mindfulness-based interventions, such as mindfulness-based childbirth and parenting (MBCP), are particularly well-suited to improve psychological responses to discomfort and pain, and pregnant women prefer non-pharmacological interventions due to concerns about side effects. However, there is a paucity of research optimizing and evaluating mindfulness- based interventions to improve prenatal sleep quality. To this end, the proposed project will optimize MBCP to improve prenatal sleep quality (MBCP-PS) and conduct pilot testing. The candidate will use state-of-the-art experience sampling methods to identify the psychological responses to nightly physical symptoms that are most robustly associated with poor sleep quality during pregnancy. Based on these findings and feedback from focus groups, the candidate will select MBCP components to maximally impact the identified targets. Finally, the candidate will conduct a pilot randomized controlled trial of MBCP-PS versus treatment as usual to investigate safety, acceptability, adherence, and feasibility, and examine preliminary evidence of change in psychological responses to nightly physical symptoms, and associations with sleep quality. Findings will provide preliminary data for an R61/R33 application to further optimize MBCP-PS and conduct an adequately powered randomized controlled trial. The proposed Mentored Patient-Oriented Research Career Development Award (Parent K23) provides substantive hands-on experiences and training in: 1) delivery and research of mindfulness-based and other mind-body interventions, 2) mechanism-focused intervention development and analysis, 3) women's perinatal health, and 4) sleep physiology, assessment, and intervention. The candidate will carry out the proposed work within an outstanding research environment. She has assembled an exceptional team of renowned mentors and specialized advisors with deep expertise on these topics to closely guide her proposed projects, and who are dedicated to her career development. The proposed award will provide the candidate with the in-depth experiences needed to establish an independent program of research focused on optimizing and evaluating mindfulness-based interventions for promoting women's health during the perinatal period.