Incorporation of Zinc and Nickel Complexes that Bind H2S and HS in ChemFET Sensing Devices

项目总结/摘要 硫化氢（H2S）是在不同环境中用于传感应用的重要分析目标，包括 环境、生物医学科学、石油和天然气工业。我的初步结果 Pluth/约翰逊实验室的工作已经建立了使用ChemFET结构检测的可行性 氢硫化物（HS-）阴离子在水溶液中。这种方法利用了HS-的检测，这是最重要的 H2S在生理条件下的普遍质子化状态，通过直接分子识别。虽然这些 初步结果提供了用ChemFET检测HS-的第一个例子，初始检测限（LoD） 目前仅适用于天然气工业;对于天然气工业，需要显著更低的检测限。 环境监测或生物环境中。为了提高这些HS传感器的适用性， 我将在ChemFET平台中构建新的识别元件。这其中的关键创新元素 研究建议通过使用新的方法进一步发展H2S和HS识别化学， 合成与H2S和HS-具有强结合相互作用的分子金属络合物， 将它们结合到ChemFET架构中，该架构已被证明显示出对以下的协同依赖性响应： HS-水溶液。我作为合成无机化学家的丰富经验加上我的经验 作为一名博士后研究员，我已经开发了ChemFET来检测各种分析物， 开发H2S或HS-检测的新技术。 除了建议的研究和作为我的专业发展的一部分，以推进我的职业目标 建立一个初创公司或在工业工作，我很高兴能报名参加，并继续参与 市场透镜（LOTM）研讨会。LOTM是一个三阶段计划，旨在让科学家了解 研究在解决人们在真实的世界中面临的挑战方面的价值。它还旨在提供 建立工作和职业机会的网络。我将进行市场调查领域的传感对传感 满足特定市场需求的技术。我已经完成了LOTM计划的第一和第二阶段，我将 继续进行第三阶段 最后，将进行研究的环境是一个跨学科的研究环境。 我经常与我的赞助商和共同赞助商互动，他们是传感，超分子， 化学，金属络合物中的小分子结合和硫化氢相关化学。许多教师 成员，包括教授。Pluth和约翰逊（发起人）是跨部门研究所的成员，如 材料科学研究所，骑士校园加速科学影响，和分子研究所 生物学，它为我提供了一个额外的互动广度。

Project Summary/Abstract Hydrogen sulfide (H2S) is an important analytical target for sensing applications in diverse settings, including the environment, biomedical sciences, and petroleum and natural gas industries. Preliminary results from my work in the Pluth/Johnson laboratories has established the feasibility of using ChemFET architectures to detect hydrosulfide (HS–) anion in aqueous solution. This approach leverages the detection of HS–, which is the most prevalent protonation state of H2S under physiological conditions, by direct molecular recognition. Although these preliminary results provide the first example of detecting HS– with a ChemFET, the initial limit of detection (LoD) of 8 mM is currently only applicable in the natural gas industry; significantly lower detection limits are needed for environmental monitoring or in biological settings. In order to improve the applicability of these HS– sensing devices I will build new recognition elements in the ChemFET platform. The key innovative element of this research proposal is to further develop H2S and HS– recognition chemistry by using a new approach of synthesizing molecular metal complexes that have strong binding interactions with H2S and HS– and incorporating them into ChemFET architectures that have proven to show concertation dependent responses to HS– in aqueous solution. My extensive experience as a synthetic inorganic chemist coupled with my experience as a post-doctoral researcher that has developed ChemFETs to sense a variety of analytes prepares me well to develop new technologies for H2S or HS– detection. In addition to the proposed research and as part of my professional development to advance my career goals of building a start-up company or working in industry, I am excited to enroll and continue to participate in the Lens of the Market (LOTM) workshop. LOTM is a three-stage program designed for scientists to learn about the value of research in addressing the challenges faced by people in the real world. It also aims to provide networking for job and career opportunities. I will perform market research in the field of sensing to pair sensing technologies with specific market needs. I have completed stages one and two of the LOTM program and I will continue on to stage three. Lastly, the environment in which the research will be performed is an interdisciplinary research environment. I interact regularly with my sponsor and cosponsor who are experts in the field of sensing, supramolecular chemistry, small molecule binding in metal complexes and hydrogen sulfide related chemistry. Many faculty members, including Profs. Pluth and Johnson (sponsors), are members of cross-department institutes, such as the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and the Institute of Molecular Biology, which provides me with an additional breadth of interactions.