Functional Genomics Training Program (FGTP)

项目总结 这个新的功能基因组学培训计划(FGTP)的目标是提供 博士前学生接受包括基础研究在内的综合培训， 生物信息学、临床遗传学和伦理学。基因组学已成为研究的基础 人类遗传病，我们认为迫切需要一个正式的培训计划， 尤其是在对人类基因组学和精确医学的兴趣不断增长的情况下 在CWRU的学生和申请者池中增长。通过这种一体化的模式， 我们的目标是让学生掌握一套关键的专业技能，以引导和塑造 以既高效又负责的态度迎接新时代的精准医疗。至 为了实现这一培训目标，我们组建了一支资金雄厚、具有凝聚力的导师团队， 以下五个关键重点领域的相关基因组学专门知识：(1)机制和 人类遗传病的治疗，(2)染色质、调节元件和RNA，(3) 生物信息学和生物统计学，(4)癌症遗传学，(5)临床遗传学，遗传学 咨询和道德。培训将包括课程作业和职能部门的实践培训 基因组学和生物信息学，以及以临床为导向的培训 跟踪临床医生，观察遗传咨询会议，并遵循临床诊断 案子。此外，由于必须确保我们在道德和社会上培养一名 负责任的下一代生物医学科学家，我们的培训模式也将包括 功能基因组学研究的伦理和潜在的社会影响，包括 基因组编辑。CWRU，有两个关键部门最近采购了 再投资(遗传学和基因组科学、人口和数量健康 科学)，人类遗传学临床中心，遗传咨询计划，遗传学 诊断实验室和两家主要医院(大学医院和克利夫兰诊所)，都是 位于1英里半径内，为我们的项目提供了理想的培训中心。我们相信 这一新项目将对研究生教育产生重大而持久的影响 CWRU作为统一全球功能基因组研究的载体 大学和大俄亥俄州东北部。

PROJECT SUMMARY The goal of this new Functional Genomics Training Program (FGTP) is to provide predoctoral students with an integrative training that encompasses basic research, bioinformatics, clinical genetics, and ethics. Genomics has become the basis for the study of human genetic disease, and we see a critical need for a formalized training program, especially as interest in human genomics and precision medicine has grown and continues to grow among students and the applicant pool at CWRU. Through this integrative model, we aim to empower students with a specialized skillset critical for ushering in and shaping the new era of precision medicine in both an efficient and responsible manner. To accomplish this training goal, we assembled a well-funded cohesive group of mentors with relevant genomics expertise in the following five key focus areas: (1) Mechanisms and Treatment of Human Genetic Disease, (2) Chromatin, Regulatory Elements, and RNA, (3) Bioinformatics and Biostatistics, (4) Cancer Genetics, (5) Clinical Genetics, Genetic Counseling and Ethics. Training will include coursework and hands on training in functional genomics and bioinformatics, along with clinically oriented training in which students shadow clinicians, observe genetic counseling sessions, and follow clinical diagnostic cases. Furthermore, as it is imperative to ensure that we train an ethically and socially responsible next generation of biomedical scientists, our training model will also incorporate ethics and the potential societal implications of functional genomics research, including genome editing. CWRU, with two key Departments that recently procured large reinvestments (Genetics and Genome Sciences, Population and Quantitative Health Sciences), a Clinical Center for Human Genetics, a Genetic Counseling Program, Genetics Diagnostic Labs, and two major hospitals (University Hospitals and the Cleveland Clinic), all located within a 1 mile radius, provides an ideal training hub for our program. We believe that this new program will have a significant and sustained impact on graduate education at CWRU by serving as a vehicle for uniting functional genomics research across the University and greater Northeast Ohio.