The Impact of Opioids on Health Outcomes for Hospitalized Infants

项目摘要 照顾住院婴儿需要一个全面的疼痛控制计划，旨在减少和预防 痛苦虽然阿片类药物通常用于婴儿经历痛苦的过程，但阿片类药物可以增加婴儿的疼痛。 短期和长期发病风险。用于住院婴儿的阿片类药物的持续时间和类型差异很大 这种巨大的差异可能会影响儿童早期发育和整体医疗保健 利用率在这项研究中，我们将通过合并儿科健康数据集来创建一个新的临床和发育数据集。 信息系统（PHIS）和加州围产期质量护理协作（CPQCC）。此合并 数据集将是第一个大型回顾性，多中心队列，代表危重病， 住院婴儿将他们的住院数据与长期神经发育结果联系起来。使用该新颖 数据集，我们将（1）确定阿片类药物使用与神经发育障碍和长期 高风险婴儿的资源利用，（2）量化接受的累积阿片类药物剂量， 高危婴儿的神经发育障碍，以及（3）量化医疗保健利用和成本的差异 与高风险婴儿中阿片类药物使用的高低有关。预期成果是一项全面的 了解高危婴儿使用阿片类药物的变化及其对神经发育的影响， 保健利用。结果将导致对住院婴儿的干预，旨在最大限度地减少 疼痛控制，也将告知政策制定者，以前没有认识到的婴儿人口需要增加 资源，以改善临床和发展成果。

PROJECT SUMMARY Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the risk of short- and long-term morbidity. The duration and type of opioids used for hospitalized infants varies widely between institutions and such wide variations could impact early childhood development and overall healthcare utilization. In this study, we will create a novel clinical and developmental dataset by merging the Pediatric Health Information System (PHIS) and the California Perinatal Quality Care Collaborative (CPQCC). This merged dataset will be the first large retrospective, multi-center cohort representing diverse populations of critically ill, hospitalized infants linking their in-hospital data with long-term neurodevelopmental outcomes. Using this novel dataset, we will (1) identify variations in opioid use associated with neurodevelopmental disability and long-term resource utilization for high-risk infants, (2) quantify cumulative opioid dosing received associated with neurodevelopmental disability for high-risk infants, and (3) quantify differences in healthcare utilization and costs associated with high vs. low opioid use among high-risk infants. The expected outcome is a comprehensive understanding of the variations in opioid use for high-risk infants and its impact on neurodevelopment and healthcare utilization. Results will lead to interventions for hospitalized infants aimed at minimizing variation in pain control and will also inform policymakers of a previously unrecognized infant population in need of increased resources to improve clinical and developmental outcomes.