To Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts

项目概要： 哥伦比亚儿童环境健康中心（CCCEH）要求支持，以保持保留和 参与其独特的环境队列，加强基本的实验室和数据管理资源， 增加社区外展，并为新的伙伴关系和培训机会奠定基础，以评估 产前暴露于环境污染物混合物的累积氧化损伤。目前，在 1,000名儿童参加了CCCEH队列，包括母亲和新生儿队列， 兄弟姐妹/兄弟姐妹队列和公平起步队列;我们预计将有1，500名总入组 到2023年的孩子。CCCEH队列由低收入和少数民族的母亲和儿童组成 （主要是非洲裔和拉丁裔）。因此，留住这些参与者至关重要， 相关的生物储存库，以及他们通过增加 参与活动，更多的实验室资源，以及增强的数据管理，准备和共享。 令人印象深刻的是，在过去的20年里，该中心收集了超过4，100，416个31，742个变量和8，478个 标准化衍生变量。在这些队列中研究的暴露包括各种有毒污染物， 化学品，包括多环芳烃（PAH）、邻苯二甲酸盐、杀虫剂、双酚A（BPA）， 环境烟草烟雾（ETS）和多溴联苯醚（PBDE）阻燃剂。中心 还收集了大量的人体测量、神经发育评估 磁共振成像（MRI）和健康记录。这种支持将促进中心的外联工作 指导行为并为政策提供信息，以减少孕妇和儿童接触有毒化学品 和污染物。它将通过整合新的生物学技术，为跨群体的新合作奠定基础。 这些措施可以为与糖尿病相关的疾病的机制提供新的见解。开发新的 作为评估线粒体DNA累积损伤的生物标志物，该中心将整合来自高通量的信息 筛选程序（如Tox 21和ToxCast™），以告知基于线粒体毒性的混合物模型。 该中心还将与西奈山医学院开展新的机构间合作， 将我们的CCCEH队列中的mtDNA测量结果与墨西哥出生队列中的相同测量结果进行比较 市鉴于迫切需要预防与环境有关的疾病和神经发育障碍， 孩子们，强大的基础设施支持是必要的，以维护和保护我们中心的独特资源， 为未来的研究方向做好准备，并确保我们的研究结果得到有效的传播。

PROJECT SUMMARY: The Columbia Center for Children’s Environmental Health (CCCEH) requests support to maintain retention and engagement of its unique environmental cohorts, enhance basic laboratory and data management resources, increase community outreach, and set the stage for new partnerships and training opportunities to evaluate cumulative oxidative damage from prenatal exposure to mixtures of environmental pollutants. Currently, over 1,000 children are enrolled in the CCCEH cohorts, including the Mothers and Newborns cohort, the Sibling/Hermanos cohort, and the Fair Start cohort; we expect that we will have a total enrollment of 1,500 children by 2023. The CCCEH cohorts are comprised of mothers and children who are low income and minority (largely African-American and Latino). Therefore, it is of critical importance to retain these participants, their associated biorepositories, and the environmental health data they have provided through increased engagement activities, more laboratory resources, and enhanced data management, preparation, and sharing. Impressively, over the past 20 years, the Center has collected over 4,100,416 for 31,742 variables and 8,478 standardized derived variables. The exposures studied in these cohorts include diverse toxic pollutants and chemicals, including polycyclic aromatic hydrocarbons (PAH), phthalates, pesticides, bisphenol A (BPA), environmental tobacco smoke (ETS), and polybrominated diphenyl ethers (PBDE) flame retardants. The Center has also collected a wealth of outcome data from anthropometric measures, neurodevelopmental assessments, magnetic resonance imaging (MRI), and health records. The support will facilitate the Center’s outreach efforts to guide behaviors and inform policies to reduce exposures of pregnant women and children to toxic chemicals and pollutants. It will lay the groundwork for new collaborations across cohorts by incorporating novel biological measures that can provide new insight on the mechanisms of exposure-related disease. To develop a novel biomarker for assessing cumulative damage in mtDNA, the Center will integrate information from high-throughput screening programs (such as Tox21 and ToxCast™) to inform mixture models based on mitochondrial toxicity. The Center will also develop a new inter-institutional collaboration with Mount Sinai School of Medicine that will compare mtDNA measures in our CCCEH cohorts with the same measures in their birth cohort from Mexico City. Given the urgent need to prevent environmentally related diseases and neurodevelopment disorders in children, strong infrastructure support is warranted to maintain and preserve our Center’s unique resources, prepare for future research directions, and ensure effective communication of our findings.